Multicenter analysis of SARS-CoV-2 vaccination and infection in patients with end-stage kidney disease
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Le résumé fourni par la source
BACKGROUND: End-stage kidney disease (ESKD) patients on dialysis or post-kidney transplantation (KT) are at high risk of coronavirus disease 2019 (COVID-19). METHOD: We retrospectively enrolled ESKD patients on hemodialysis (HD), peritoneal dialysis (PD), and post-KT between January 2020 to December 2022 across eight medical centers in Taiwan. This study analyzed demographics, vaccination coverage, antiviral use, and COVID-19 severity in these patients. RESULTS: A total of 5950 ESKD patients were analyzed: 3233 (54.3 %) on HD, 1592 (26.8 %) on PD, and 1125 (18.9 %) post-KT. Overall, 83.1 % of patients received at least one dose of vaccine. HD patients had the highest vaccination coverage (89.9 %) but also the highest infection rates (26.2 %), antiviral use (82.4 %), and COVID-19-related mortality (5.3 %). KT recipients had the lowest vaccination coverage (66.8 %) and the highest intensive care unit (ICU) admission (9.3 %), while PD patients had the lowest mortality (0.4 %). Regionally, vaccination was lowest among Northern KT recipients (20.7 %), infection peaked among Eastern HD patients (41.2 %), and severe outcomes were concentrated in Eastern KT recipients, who also had the highest mortality (14.7 %). Logistic regression analysis demonstrated that older age increased the risks of hospitalization and mortality, while vaccination provided a clear dose-dependent protective effect across all outcomes. CONCLUSIONS: Vaccination was associated with reduced hospitalization and death among ESKD patients. HD patients bore the highest infection burden, KT recipients were most vulnerable to severe outcomes, and PD patients had the most favorable prognosis. These finding emphasize the importance of improving vaccine coverage, particularly among KT recipients.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Multicenter analysis of SARS-CoV-2 vaccination and infection in patients with end-stage kidney disease
- Date Crossref
- 01/01/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Chang Gung University Department of Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
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Kaohsiung Chang Gung Memorial Hospital pays non établi dans la noticeÉtablissement de santé
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Kaohsiung Medical University Department of Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
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National Taiwan University Hospital Department of Internal Medicine pays non établi dans la noticeÉtablissement de santé
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Fu Jen Catholic University pays non établi dans la noticeUniversité ou école supérieure
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Taichung Veterans General Hospital Department of Internal Medicine pays non établi dans la noticeÉtablissement de santé
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Hualien Tzu Chi Medical Center pays non établi dans la noticeÉtablissement de santé
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Kaohsiung Veterans General Hospital Department of Internal Medicine pays non établi dans la noticeOrganisme public
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National Defense Medical Center pays non établi dans la noticeÉtablissement de santé
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National Cheng Kung University Hospital Department of Internal Medicine pays non établi dans la noticeÉtablissement de santé
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Hualien Tzu Chi General Hospital Department of Internal Medicine pays non établi dans la noticeÉtablissement de santé
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National Defense Medical University Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
Department of Internal Medicine — Chang Gung University, Kaohsiung Chang Gung Memorial Hospital et Department of Internal Medicine — Kaohsiung Medical University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.