The response to kidney injury is epigenetically regulated through the activation of bivalent genes

Le résumé fourni par la source

We performed the first identification of bivalent domains in the adult mouse kidney. We identified bivalent genes that, when activated after kidney injury, drive inflammation, proliferation, and fibrosis. Activation of bivalent genes is coordinated by transcription factors such as Spi1. Our research not only provides a valuable database of bivalent genes in the kidney but also demonstrates that activation of bivalent genes is crucial for the progression from acute to chronic kidney injury.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.