Baseline geriatric 8 (G8) screening tool predicts overall survival in metastatic urothelial carcinoma treated with immune checkpoint inhibitors
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Le résumé fourni par la source
BACKGROUND: Metastatic urothelial carcinoma (mUC) remains highly lethal despite advances in treatment. There is limited data surrounding the efficacy and toxicity of immune checkpoint inhibitors in treating elderly patients due to the high bar of clinical trial participation. The Geriatric 8 (G8) screening tool is a quick, 8-item questionnaire designed to assess frailty in older adults. This study evaluates the G8 tool's utility in predicting overall survival (OS) and progression-free survival (PFS) in patients with mUC treated with immune checkpoint inhibitors. MATERIALS AND METHODS: A retrospective analysis was conducted on 48 mUC patients treated with ICI monotherapy at Winship Cancer Institute between 2016 and 2019. Baseline G8 scores were calculated from clinical notes. Primary outcomes included OS and PFS, analyzed using Kaplan-Meier, Cox proportional hazards models, and multivariate analysis adjusted for demographic and clinical variables. RESULTS: An impaired baseline G8 score predicted worse OS but not PFS. The incidence of immune-related adverse events was lower but not statistically significant in patients with impaired G8 scores (HR, 0.31; OR, 0.09-1.14; P = .077). CONCLUSION: The G8 screening tool effectively predicts OS in older mUC patients treated with ICIs, highlighting its potential utility in clinical decision-making. Frail patients, as identified by the G8, had significantly worse survival outcomes, underscoring the need for tailored therapeutic approaches in this vulnerable population. Further studies are warranted to validate these findings and explore interventions that may improve outcomes for frail, older patients with mUC.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Baseline geriatric 8 (G8) screening tool predicts overall survival in metastatic urothelial carcinoma treated with immune checkpoint inhibitors
- Date Crossref
- 24/12/2025
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Georgia pays non établi dans la noticeUniversité ou école supérieure
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Augusta University pays non établi dans la noticeUniversité ou école supérieure
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Emory University Department of Biostatistics and Bioinformatics pays non établi dans la noticeUniversité ou école supérieure
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Massachusetts General Hospital Department of Medicine pays non établi dans la noticeÉtablissement de santé
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Columbia University pays non établi dans la noticeUniversité ou école supérieure
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Piedmont Cancer Institute pays non établi dans la noticeÉtablissement de santé
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Medical College of Georgia pays non établi dans la noticeUniversité ou école supérieure
University of Georgia, Augusta University et Department of Biostatistics and Bioinformatics — Emory University, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.