Accès ouvert déclaré 2025 article

Association of alcohol and different types of alcoholic beverages on the risk of buccal mucosa cancer in Indian men: a multicentre case-control study

Grace Sarah George, Aniket Patil, Romi Moirangthem, Pravin Narayanrao Doibale, Ankita Manjrekar, Shruti Vishwas Golapkar, Nandkumar S Panse, Manigreeva Krishnatreya, Aseem Mishra, Arjun Singh, Harriet Rumgay, Bayan Hosseini, Anil Chaturvedi, Preetha Rajaraman, Ann C. Olsson, Isabelle Soerjomataram, P. Chaturvedi, Rajesh Prabhakar Dikshit, Sharayu Mhatre

2Citations signalées, ce qui n’est pas une note de qualité

11Institutions déclarées

4Pays d’affiliation déclarés

Rattachement africain : in, fr, us, jp. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

INTRODUCTION: While a large proportion of buccal mucosa cancer (BMC) is attributed to tobacco use, the contribution of alcohol is little-known. In India, alcohols include internationally-recognised (IRL) and locally-brewed liquor (LBL) types, which might contribute differently to the risk of BMC. We conducted an observational study to evaluate the association of local and foreign alcoholic beverage use on the risk of developing BMC. METHODS: Data from 1803 BMC cases and 1903 visitor controls from a multicentric case-control study was analysed for 11 IRLs and 30 LBLs. Healthy visitor controls were randomly sampled from the source population of the study centres which enrolled the cases. Quantitative data on the amount, the number of times consumed per day or week, and the lifetime duration of consumption for each of the alcoholic beverages were collected using an interviewer administered standardised questionnaire, which was then used to estimate the grams per day consumption of alcohol. Odds ratios (OR) and 95% CI were estimated after adjustment for potential confounders, including tobacco use. The joint effect of tobacco and alcohol on BMC risk, the attributable fraction (AF) of cases and state-wise population attributable fraction (PAF) were estimated. RESULTS: An increased risk of 1.68 (95% CI=1.44-1.97), 1.72 (95% CI=1.46-2.04), and 1.87 (95% CI=1.46-2.39) was observed for ever-users of any alcohol, IRLs and LBLs, respectively for BMC. The findings show 9 grams/day of alcohol increased the risk of BMC by approximately 50%, and 62% of cases could be attributed to alcohol drinking and chewing tobacco, with an overall PAF of 11.3% for India. CONCLUSION: This study shows that alcohol, even in low quantities, increases the risk for BMC. Prevention of consumption of tobacco and alcohol together could substantially reduce the incidence of BMC.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.

Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Association of alcohol and different types of alcoholic beverages on the risk of buccal mucosa cancer in Indian men: a multicentre case-control study
Date Crossref: 01/12/2025
Éditeur: BMJ
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

Homi Bhabha National Institute pays non établi dans la notice
Université ou école supérieure
Advanced Centre for Treatment pays non établi dans la notice
Établissement de santé
Nargis Dutt Memorial Cancer Hospital pays non établi dans la notice
Établissement de santé
Bhubaneswar Borooah Cancer Institute pays non établi dans la notice
Établissement de santé
Madan Mohan Malaviya University of Technology pays non établi dans la notice
Université ou école supérieure
Mahamana Pandit Madan Mohan Malaviya Cancer Centre pays non établi dans la notice
Organisme public
Tata Memorial Hospital Department of Head and Neck Oncology pays non établi dans la notice
Établissement de santé
Centre international de recherche sur le cancer pays non établi dans la notice
Organisme public
National Cancer Institute Division of Cancer Epidemiology and Genetics pays non établi dans la notice
Organisme public
Division of Cancer Epidemiology and Genetics pays non établi dans la notice
Structure de recherche
Radiation Effects Research Foundation pays non établi dans la notice
Structure de recherche
Division of Molecular Epidemiology and Population Genomics pays non établi dans la notice
Institution

Homi Bhabha National Institute, Advanced Centre for Treatment et Nargis Dutt Memorial Cancer Hospital, avec 9 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Head and Neck Cancer StudiesOral Health Pathology and TreatmentAlcohol Consumption and Health Effects

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