Hypogonadism and cancer incidence in men with Klinefelter syndrome

Le résumé fourni par la source

Klinefelter Syndrome (KF) affects around 1 in 500 to 1 in 1000 men, and is associated with numerous complications including infertility, metabolic syndrome, and osteoporosis.1 KF is also thought to be associated with an increased risk of certain malignancies. Proposed mechanisms for this increased risk include direct effects of an extra X chromosome and hormonal imbalances.2 Some smaller cohort studies have been previously done to assess this increased risk. For example, a prospective cohort study of 3500 KF patients by Swerdlow et al. found KF was associated with increased risk of non-Hodgkin lymphoma, lung, and breast cancer.2 However, this study only included data from patients from 27 cytogenetics laboratories in Britain. Another study of 433 KF patients also found KF was associated with increased risk of mediastinal germ cell tumors (GCT).3 Nonetheless, this study only included data from a pediatric cancer research network database. As no previous studies have done so, we aimed to investigate risks of malignancy on a population-level and also to assess impacts of hypogonadism (HG). We hypothesized that on the population level, KF would be associated with similar malignancies that have been previously described, and that controlling for HG would eliminate the risk of certain malignancies that may be due to hormonal-related mechanisms.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.