Cortical asymmetry in autosomal dominant Alzheimer’s disease progression
Rattachement africain : es, co, ar, us, au, jp, de, ca, vn. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract The cortical asymmetry index evaluates the cortical thickness asymmetry between hemispheres. We investigated cortical asymmetry index in asymptomatic and symptomatic mutation carriers of autosomal dominant Alzheimer’s disease to explore the brain asymmetry within the Alzheimer’s disease continuum. Sixty baseline T1-weighted MRI scans were obtained from the Clinic Barcelona cohort. Baseline and longitudinal MRI data from 564 participants within the dominantly inherited Alzheimer network observational study were used as an independent, confirmatory cohort. Cerebrospinal fluid and plasma neurofilament light chain levels were included when available. Cortical thickness was calculated using Freesurfer and cortical asymmetry index was calculated via an open-source pipeline. Cross-sectional analyses examined cortical asymmetry index differences based on clinical classification and APOE ε4 status, adjusting for age, sex and estimated years from onset, while correlations were assessed with age, estimated years from onset, mini-mental state examination scores, and neurofilament light. Longitudinal cortical asymmetry index evolution was modelled using generalized additive models in the dominantly inherited Alzheimer network observational study cohort, incorporating age, sex, and the interaction between group and estimated years from onset. The cortical asymmetry index successfully distinguished asymptomatic mutation carrier and symptomatic mutation carriers from healthy controls in the Clinic Barcelona cohort and symptomatic mutation carriers from controls in dominantly inherited Alzheimer network observational study. Higher cortical asymmetry index in mutation carriers (asymptomatic mutation carrier and symptomatic mutation carriers combined) and in symptomatic mutation carriers were associated with higher plasma neurofilament light levels, a closer proximity to symptom onset, and lower mini-mental state examination in the Clinic Barcelona cohort. In the dominantly inherited Alzheimer network observational study cohort, mutation carriers exhibited increased cortical asymmetry index compared to controls and correlated with elevated neurofilament light (plasma and Cerebrospinal fluid), lower mini-mental state examination, and a closer proximity to symptom onset. APOE3/3 carriers showed greater asymmetry than other APOE genotypes and significant cortical asymmetry index differences between asymptomatic mutation carrier and symptomatic mutation carriers. Longitudinally, cortical asymmetry index increased over time significantly in symptomatic mutation carriers. These findings underscore brain asymmetry as a potential biomarker for early Alzheimer’s disease progression in autosomal dominant Alzheimer’s disease, with implications for detection and monitoring tracking disease-related neuroanatomical changes.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Cortical asymmetry in autosomal dominant Alzheimer’s disease progression
- Date Crossref
- 19/12/2025
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Universitat Oberta de Catalunya pays non établi dans la noticeUniversité ou école supérieure
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Biomedical Research Networking Center on Neurodegenerative Diseases pays non établi dans la noticeStructure de recherche
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Hospital Clínic de Barcelona Service of Neurology pays non établi dans la noticeÉtablissement de santé
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Fundació Clínic per a la Recerca Biomèdica pays non établi dans la noticeOrganisation à but non lucratif
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Departament de Salut pays non établi dans la noticeOrganisme public
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Instituto de Salud Carlos III CIBER de Salud Mental pays non établi dans la noticeOrganisme public
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Centro de Investigación Biomédica en Red de Salud Mental pays non établi dans la noticeStructure de recherche
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Universidad de Antioquia pays non établi dans la noticeUniversité ou école supérieure
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Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia pays non établi dans la noticeOrganisation à but non lucratif
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Neurological Research Institute pays non établi dans la noticeInstitution
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Jacksonville College pays non établi dans la noticeUniversité ou école supérieure
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Neuroscience Research Australia pays non établi dans la noticeStructure de recherche
Universitat Oberta de Catalunya, Biomedical Research Networking Center on Neurodegenerative Diseases et Service of Neurology — Hospital Clínic de Barcelona, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.