From XenoMouse® Technology to Panitumumab (ABX-EGF)

Le résumé fourni par la source

Recent success of antibody therapeutics in oncology has revived a keen interest in the development of monoclonal antibodies (mAbs) for the treatment of cancer. To date, eight mAbs have been approved in the United States for the treatment of hematological malignancies or solid tumors. The increased success has been largely attributed to advances in antibody technology such as chimerization and humanization of mAbs and the development of fully human antibodies allowing for reduction in immunogenicity and creation of antibodies of desired affinity and isotype. XenoMouse® technology is a technology that allows for the generation of fully human mAbs in transgenic mice. Using this technology, the anti-epidermal growth factor receptor (EGFR) antibody, panitumumab, has been created. Panitumumab (ABX-EGF) is a fully human IgG2 anti-EGFR mAb. Panitumumab binds EGFR with high affinity, inhibits ligand-dependent receptor activation, and effectively inhibits the growth of multiple human tumor xenografts in mouse models. To date, in phase 1 and phase 2 clinical studies, panitumumab has been generally well tolerated, exhibited no immunogenicity, and demonstrated low interpatient and intrapatient pharmacokinetic variability. Objective responses have been observed in patients with metastatic colorectal cancer and advanced renal cell carcinoma.

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