Combined Effects of Pulmonary Hypertension and Heart Valve Calcification on Cardiovascular Outcomes in Maintenance Hemodialysis Patients: A Risk Stratification Study Using Echocardiography
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Le résumé fourni par la source
Introduction: Cardiovascular disease remains the leading cause of mortality in maintenance hemodialysis (MHD) patients. While both pulmonary hypertension (PH) and heart valve calcification (HVC) are established independent risk factors for adverse outcomes in this population, the synergistic effect of these two echocardiographic parameters on cardiovascular prognosis has not been well investigated. Methods: In this prospective study, we analyzed clinical and echocardiographic data from 302 MHD patients over a two-year follow-up period. Patients were stratified into three groups based on the presence of risk factors: group 1 (no risk factors), group 2 (either PH or HVC), and group 3 (both PH and HVC). Survival analysis was performed using Kaplan-Meier curves, and Cox regression models were employed to evaluate the impact on all-cause mortality, cardiovascular mortality, and new-onset cardiovascular events (CV events). Results: < 0.001). The presence of both PH and HVC was associated with a higher risk of all-cause mortality, cardiovascular mortality, and new-onset CV events compared to either PH or HVC alone. After adjusting for confounders, the combination of PH and HVC remained a significant predictor, demonstrating a higher risk than having a single risk factor (hazard ratio [HR] for all-cause mortality: 3.76 [95% CI: 1.83-7.73] vs. 1.90 [95% CI: 1.03-3.52]; HR for cardiovascular mortality: 9.23 [95% CI: 3.42-24.95] vs. 3.11 [95% CI: 1.23-7.84]; HR for new-onset CV events: 4.21 [95% CI: 2.39-7.21] vs. 1.68 [95% CI: 1.01-2.76]). Conclusion: The coexistence of PH and HVC significantly increases cardiovascular risk compared to either condition alone in MHD patients. Echocardiography is a valuable tool for screening and risk stratification in this high-risk population by identifying both PH and HVC.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Combined Effects of Pulmonary Hypertension and Heart Valve Calcification on Cardiovascular Outcomes in Maintenance Hemodialysis Patients: A Risk Stratification Study Using Echocardiography
- Date Crossref
- 19/12/2025
- Éditeur
- S. Karger AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Guangdong Academy of Medical Sciences pays non établi dans la noticeÉtablissement de santé
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Guangdong Provincial People's Hospital pays non établi dans la noticeÉtablissement de santé
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Southern Medical University Department of Nephrology pays non établi dans la noticeUniversité ou école supérieure
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People’s Hospital of Linqing pays non établi dans la noticeÉtablissement de santé
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The People's Hospital of LinXia pays non établi dans la noticeÉtablissement de santé
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Guangdong Cardiovascular Institute Department of Nephrology pays non établi dans la noticeStructure de recherche
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Heyuan People's Hospital Department of Nephrology pays non établi dans la noticeÉtablissement de santé
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Linzhi People's Hospital Department of Nephrology pays non établi dans la noticeÉtablissement de santé
Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital et Department of Nephrology — Southern Medical University, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.