Baseline exposure–response assessment of metals from dried blood spots and personal household air pollution concentrations among pregnant women in Rwanda: household air pollution intervention network trial

Le résumé fourni par la source

Exposure to metals from the combustion of biomass via inhalation may result in negative health outcomes affecting a variety of organs and systems. Pregnant women cooking with biomass fuels may be exposed to metals, such as lead (Pb) and cadmium (Cd), and have unique risks for adverse health effects with potential impacts on the growing fetus. We assessed the associations between household air pollution and metals detected in dried blood spots from pregnant women at baseline in Rwanda. We analyzed data from 781 pregnant women aged 18–35 years who resided in rural households using biomass fuel and who were enrolled in the Household Air Pollution Intervention Network (HAPIN ) Trial in Rwanda. We explored associations between 24-h average natural log-transformed personal exposures to fine particulate matter (PM 2.5 ), black carbon (BC), and carbon monoxide (CO) and K + standardized Pb and Cd concentrations using linear regression models adjusted for potential confounders (i.e., age, body mass index, bicycle ownership, fish consumption, and food insecurity). The adjusted models showed positive but non-significant associations between air pollutant concentrations and metals detected in blood: PM₂.₅ and Pb (β coefficient: 0.06; 95% CI − 0.03–0.15), BC and Pb (0.11; 95% CI − 0.01–0.24), PM₂.₅ and Cd (0.04; 95% CI − 0.02–0.09), and BC with Cd (0.02; 95% CI − 0.05–0.09). While associations were not statistically significant, the directionally consistent increases in blood Pb and Cd with increased PM₂.₅ and BC exposures align with existing evidence and underscore the need for continued research and policy action to reduce household air pollution exposures and protect maternal and fetal health.

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