Spatial patterns and prognostic relevance of CD1a+ immature and CD208+ mature dendritic cells in colorectal cancer from non-tumor adjacent mucosa to liver metastases
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Le résumé fourni par la source
Abstract The prognostic role of dendritic cells (DCs) in colorectal cancer (CRC) and paired liver metastases (LM) remains unclear, particularly regarding the dynamics of immature CD1a + and mature CD208 + subsets across anatomical compartments and synchronous versus metachronous disease. Patients and methods. This retrospective cohort included patients undergoing resection of primary CRC (pCRC) and synchronous LM ( N = 55) or metachronous LM ( N = 44). Immunohistochemical staining for CD1a and CD208 was performed on non-tumor adjacent mucosa (NAM), as well as tumor center (TC), inner margin (IM), outer margin (OM), and peritumoral zone (PT) of both pCRC and LM. Cell densities were quantified on whole-slide images using QuPath software and correlated with overall survival (OS). Results. CD1a + DCs were nearly absent in NAM but enriched in pCRC TC, whereas CD208 + DCs predominated in lymphoid aggregates associated with NAM and peripheral compartments of pCRC and LM. CD1a + cells followed a TC/IM > OM/PT gradient, while CD208 + cells showed the opposite, consistent with a recruitment–maturation axis. In synchronous cases, CD1a + densities were higher in pCRC than LM, supporting the role of the primary tumor as a “monocyte reservoir.” Survival analysis revealed that high CD208 + density in TC of synchronous LM (hazard ratio (HR) = 0.47; p = 0.033) and high CD1a + density in TC of metachronous LM (HR = 0.44; p = 0.050) were both associated with reduced mortality risk. Conclusion. This study provides the first detailed mapping of CD1a + and CD208 + DCs across NAM, pCRC and paired LM, indicating that their prognostic impact is determined not only by absolute numbers but, more importantly, by compartmental distribution and the temporal pattern of metastasis.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Spatial patterns and prognostic relevance of CD1a+ immature and CD208+ mature dendritic cells in colorectal cancer from non-tumor adjacent mucosa to liver metastases
- Date Crossref
- 18/12/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Charles University pays non établi dans la noticeUniversité ou école supérieure
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Technical University of Liberec pays non établi dans la noticeUniversité ou école supérieure
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Krajská Nemocnice Liberec pays non établi dans la noticeÉtablissement de santé
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German Cancer Research Center Department of Cancer Epidemiology pays non établi dans la noticeStructure de recherche
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Heidelberg University pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine in Pilsen Laboratory of Translational Cancer Genomics pays non établi dans la noticeUniversité ou école supérieure
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Regional Hospital Liberec The Department of Pathology pays non établi dans la noticeÉtablissement de santé
Charles University, Technical University of Liberec et Krajská Nemocnice Liberec, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.