Incident Pulmonary Hypertension and Its Risk Factors in CKD
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Le résumé fourni par la source
KEY POINTS: Lower eGFR and higher B-type natriuretic peptide are associated with increased odds of developing pulmonary hypertension. Albuminuria was not associated with the development of incident pulmonary hypertension. BACKGROUND: Pulmonary hypertension (PH) is a common comorbid condition in patients with CKD and is associated with high mortality. We sought to identify the incidence of PH and the relation of kidney function and volume status to its development in a large cohort of patients with CKD. METHODS: The study sample included 1076 participants from the Chronic Renal Insufficiency Cohort Study with two or more measurements of tricuspid regurgitation velocity by transthoracic echocardiography. Incident PH was defined as a tricuspid regurgitation velocity of ≥2.8 m/s (reflecting a right ventricular systolic pressure gradient ≥31 mm Hg). Multivariable logistic regression adjusting for demographics, comorbid conditions, and medications was used to evaluate the relation of kidney function (eGFR and albuminuria) as well as B-type natriuretic peptide (BNP) to incident PH. RESULTS: Over a median of 3.0 years, 120 patients developed incident PH (incidence rate 2.70 cases per 100 person-years). Each 10 ml/min per 1.73 m 2 lower eGFR was associated with 29% (odds ratio, 1.29; 95% confidence interval, 1.10 to 1.52) higher odds of the development of PH after adjustment for confounders, while each doubling of BNP was associated with a 32% (odds ratio, 1.32; 95% confidence interval, 1.15 to 1.51) higher odds. There was no significant relation between urine albumin excretion and incident PH. CONCLUSIONS: eGFR and BNP were independently associated with the development of incident PH. Closer attention to these potentially modifiable risk factors is warranted to slow the progression of this common comorbidity of patients with CKD.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Incident Pulmonary Hypertension and Its Risk Factors in CKD
- Date Crossref
- 01/12/2025
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Tufts University Tufts Clinical and Translational Science Institute pays non établi dans la noticeUniversité ou école supérieure
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Tufts Medical Center pays non établi dans la noticeÉtablissement de santé
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The University of Osaka pays non établi dans la noticeUniversité ou école supérieure
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Baylor College of Medicine pays non établi dans la noticeUniversité ou école supérieure
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University of Pennsylvania Departments of Medicine and Epidemiology pays non établi dans la noticeUniversité ou école supérieure
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Osaka University Graduate School of Medicine pays non établi dans la noticeUniversité ou école supérieure
Tufts Clinical and Translational Science Institute — Tufts University, Tufts Medical Center et The University of Osaka, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.