Preoperative nutritional support in children with Hirschsprung disease: a prospective multicenter open-label randomized controlled trial
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Le résumé fourni par la source
Preoperative undernutrition is prevalent among children with Hirschsprung disease (HSCR). To evaluate whether preoperative nutritional support reduces the incidence of postoperative HSCR-associated enterocolitis (HAEC), we conducted a prospective, multicenter, open-label randomized controlled trial. The trial was initiated on January 1, 2021 and completed on October 31, 2022. It was carried out across seven tertiary hospitals in China. A total of 110 patients admitted for pull-through surgery for HSCR were enrolled. Eligible participants were randomly assigned 1:1 via a centralized web-based randomization system ( www.cbdps.com ), which generated the allocation sequence. Specifically, 55 patients were allocated to the preoperative nutritional support (PNS) group and 55 to the standard medical care (SMC) group. Surgeons and patients were not blinded to group assignment. The primary outcome was the incidence of HAEC at 3 months after surgery. At 3 months postoperatively, the incidence of HAEC in the PNS group was significantly lower compared to the SMC group. Specifically, the HAEC incidence was 7.27% (4/55) for the PNS group versus 29.09% (16/55) for the SMC group. This resulted in an absolute risk reduction of 21.82% (95% confidence interval: −35.64% to −7.99%; p = 0.003). No adverse events were documented. These results demonstrate that preoperative nutritional support substantially reduces early HAEC incidence in pediatric HSCR patients following pull-through surgery. Trial Registration: ClinicalTrials.gov NCT04598841. Hirschsprung disease, characterized by the absence of ganglion cells leading to functional bowel obstruction, can be treated with surgery. Here, the authors report that preoperative nutritional support in children with Hirschsprung disease reduced the risk of postoperative enterocolitis by comparison to standard of care in a randomized controlled trial.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Preoperative nutritional support in children with Hirschsprung disease: a prospective multicenter open-label randomized controlled trial
- Date Crossref
- 19/12/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Hubei Provincial Center for Disease Control and Prevention pays non établi dans la noticeOrganisme public
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Tongji Hospital pays non établi dans la noticeÉtablissement de santé
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Huazhong University of Science and Technology Department of Pediatric Surgery pays non établi dans la noticeUniversité ou école supérieure
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Anhui Provincial Children's Hospital Department of Pediatric Surgery pays non établi dans la noticeÉtablissement de santé
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Shanghai Jiao Tong University pays non établi dans la noticeUniversité ou école supérieure
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Shanghai Children's Hospital pays non établi dans la noticeÉtablissement de santé
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Xi’an Children’s Hospital Department of Pediatric Surgery pays non établi dans la noticeÉtablissement de santé
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Tianjin Children's Hospital Department of General Surgery pays non établi dans la noticeÉtablissement de santé
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First Affiliated Hospital of Zhengzhou University Department of Pediatric Surgery pays non établi dans la noticeÉtablissement de santé
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Shanxi Provincial Children's Hospital pays non établi dans la noticeÉtablissement de santé
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Hubei Clinical Center of Hirschsprung Disease and Allied Disorders pays non établi dans la noticeÉtablissement de santé
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School of Medicine Department of General Surgery pays non établi dans la noticeUniversité ou école supérieure
Hubei Provincial Center for Disease Control and Prevention, Tongji Hospital et Department of Pediatric Surgery — Huazhong University of Science and Technology, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.