A Novel Tool for In-Situ Real-Time Dose Monitoring During Cancer Particle Therapy

Le résumé fourni par la source

Innovative classes of materials such as organic semiconductors and perovskites have been studied in the last decade for the detection of ionizing radiation. In particular, organic semiconductors gained a growing attention to the field of medical dosimetry, thanks to their intrinsic human tissue equivalence and high radiation tolerance. We here present a wearable, tissue-equivalent dosimeter capable of real-time monitoring of radiation absorbed by patients undergoing cancer treatment. This fully organic device was tested under real clinical conditions using a high-energy proton beam and an anthropomorphic phantom to simulate proton therapy for prostate cancer. We achieved complete control over the dosimeter's operation and demonstrated its linear response to administered dose. By appropriately functionalizing the polysiloxane-based scintillator, we enabled the device to effectively detect various types of ionizing radiation. In addition to protons, we also developed a version of the device capable of detecting thermal neutrons, aiming for its application in Boron Neutron Capture Therapy. This work highlights the potential of organic indirect detectors as a versatile platform for in situ, real-time monitoring of radiation doses absorbed by patients across different types of cancer treatments.

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