Neisseria gonorrhoeae Sequence Types During an Increase of Gonorrhea Among Young Women in 2022 and 2023 in the Netherlands
Rattachement africain : nl, tw, ca. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Background Since September 2022, an ongoing increase in gonorrhea positivity rates and diagnoses among young women visiting sexual health centers was observed in the Netherlands. To gain more insight into possible drivers of this increase, this study aimed to investigate the molecular diversity, clustering, and transmission of Neisseria gonorrhoeae related to the gonorrhea increase in the Netherlands. Methods Between January 2022 and March 2023, viable and stored N gonorrhoeae isolates from vaginal swab samples from 273 women <25 years of age were included from 4 sexual health centers in the Netherlands. All isolates were subjected to whole genome sequencing. The molecular diversity was investigated by analyzing (core genome) multilocus sequence types (STs) over time and by patient characteristics. Results The prevalence of ST7359 and ST7822 increased from <5% in the beginning of 2022 to ∼23% in 2023 and ST9363 from 6% to 14%. ST7359 and ST9363 were associated with hosts with university-level education and Dutch ethnicity. ST7359 and ST7822 also included large clusters of genetically related isolates (<6-gene difference). No indication for reduced antimicrobial susceptibility to ceftriaxone was found in any ST. Conclusions The N gonorrhoeae surge among young women is not caused by a single strain. The prevalence of STs shifted over time, and certain STs were associated with distinct populations and showed clustering of genetically related isolates. These findings suggest rapid clonal expansion of several circulating STs. This may be indicative of increased transmission within specific sexual networks.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- <i>Neisseria gonorrhoeae</i> Sequence Types During an Increase of Gonorrhea Among Young Women in 2022 and 2023 in the Netherlands
- Date Crossref
- 15/12/2025
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Maastricht University Department of Social Medicine pays non établi dans la noticeUniversité ou école supérieure
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National Institute for Public Health and the Environment Department of Epidemiology and Surveillance pays non établi dans la noticeStructure de recherche
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Department of Health pays non établi dans la noticeOrganisme public
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GGD Amsterdam pays non établi dans la noticeÉtablissement de santé
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Erasmus MC Department of Medical Microbiology and Infectious Diseases pays non établi dans la noticeÉtablissement de santé
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GGD Rotterdam-Rijnmond pays non établi dans la noticeOrganisme public
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Medisch Centrum Haaglanden pays non établi dans la noticeÉtablissement de santé
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Stichting Haaglanden Medisch Centrum pays non établi dans la noticeÉtablissement de santé
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Amsterdam Neuroscience pays non établi dans la noticeStructure de recherche
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Amsterdam University Medical Centers pays non établi dans la noticeÉtablissement de santé
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Amsterdam institute for Immunology and Infectious Diseases Department of Dermatology pays non établi dans la noticeÉtablissement de santé
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University of Amsterdam pays non établi dans la noticeUniversité ou école supérieure
Department of Social Medicine — Maastricht University, Department of Epidemiology and Surveillance — National Institute for Public Health and the Environment et Department of Health, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.