The Postnatal outcomES of Fetal Cortical mAlformations ( PESCA ) Study: A Multicentre Historical Cohort Study
Rattachement africain : gb, es, it. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
OBJECTIVES: To provide further evidence on the outcomes associated with fetal malformations of cortical development (MCD), currently informed by data from symptomatic paediatric cohorts, this study provides a new classification system. DESIGN: Multicentre retrospective cohort study. SETTING: Fetal medicine units of three tertiary centres in the United Kingdom and Italy. POPULATION: 118 foetuses diagnosed with MCD by ultrasound and/or magnetic resonance imaging included. METHODS: The cases were classified according to their presumed aetiology (genetic, haemorrhage, dysgenesis, infection) and imaging findings (focal, diffuse, mantle, sulcation). Neurodevelopmental delay was classified as mild, moderate or severe. Cases with missing information on postnatal outcome were excluded. MAIN OUTCOME MEASURES: Postnatal neurodevelopmental outcome ascertained from the infant's neurological assessments according to international performance scales, depending on the age. RESULTS: There were 52/118 (44%) livebirths, 64/118 (54.2%) terminations of pregnancy (TOP) and 2/118 (1.6%) intrauterine demises. Twenty-five of 46 cases (54.3%, 95% CI 39-69.1) that survived the neonatal period had a normal or mildly delayed neurological development. The commonest aetiology was genetic, and the most frequent radiological finding was reduced sulcation. The best neurological outcome was found in children with focal lesions; those with diffuse hemispheric lesions had the worst one. CONCLUSION: This is the largest cohort of foetuses diagnosed with MCDs systematically classified by aetiology and radiological findings. In this retrospective cohort of liveborn survivors, over half had normal or mildly abnormal neurodevelopmental outcomes. Prognosis varied according to lesion pattern and suspected aetiology. Fetal MCDs in this study had better neurodevelopmental outcomes than previously reported, though findings should be interpreted with caution given selection and follow-up limitations.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- The Postnatal <scp>outcomES</scp> of Fetal Cortical <scp>mAlformations</scp> ( <scp>PESCA</scp> ) Study: A Multicentre Historical Cohort Study
- Date Crossref
- 15/12/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of London Fetal Medicine Unit pays non établi dans la noticeUniversité ou école supérieure
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St George’s University Hospitals NHS Foundation Trust Fetal Medicine Unit pays non établi dans la noticeÉtablissement de santé
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Instituto de Investigación Sanitaria Aragón pays non établi dans la noticeInstitution
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Agostino Gemelli University Polyclinic pays non établi dans la noticeÉtablissement de santé
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University of Parma pays non établi dans la noticeUniversité ou école supérieure
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Instituto de Investigación Sanitaria de Aragón Zaragoza Spain pays non établi dans la noticeStructure de recherche
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Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy Department of Obstetrics and Gynaecology Università Cattolica del Sacro Cuore pays non établi dans la noticeÉtablissement de santé
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Department of Medicine and Surgery Unit of Surgical Sciences pays non établi dans la noticeInstitution
Fetal Medicine Unit — University of London, Fetal Medicine Unit — St George’s University Hospitals NHS Foundation Trust et Instituto de Investigación Sanitaria Aragón, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.