Electrochemical Dehydroxymethylative Functionalization of Unactivated Alcohols via Criegee–Kolbe Radical Relay

Le résumé fourni par la source

Direct dehydroxymethylative functionalization of alcohols offers a streamlined platform for molecular diversification but remains underdeveloped. An electrochemical platform operating under mild, metal-free conditions leverages a hydrogen atom transfer (HAT)/O 2 –Criegee relay to convert various alcohols (such as aliphatic, benzylic, and allylic alcohols) into one-carbon-shortened radicals, enabling dehydroxymethylative nitration, fluorosulfonylation, azidation, and phosphinoylation with broad functional-group tolerance and gram-scale practicality. Pairing the anodic radical generation with a cathodic Ni cycle further delivers C(sp 2 )–C(sp 3 ) coupling, including the one-step methylation of aryl halides using ethanol as a feedstock methyl source. Mechanistic experiments (control studies and electron paramagnetic resonance/high-resolution mass spectrometry/cyclic voltammetry) support a sequence of HAT, O 2 trapping, Criegee assembly, Baeyer–Villiger oxygenation, anodic decarboxylation, and radical interception and indicate mediator-first anodic gating. The platform expands access to C–N, C–SO 2 F, C–P, and C–C bonds directly from simple alcohols, providing a general strategy for selective editing of inert C–C bonds and late-stage diversification of biorelevant molecules.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.