Accès ouvert déclaré2025article
Hepatitis B Surface Antibody Clearance After Vaccination in People With HIV
Axel Ursenbach, François Séverac, Archia Chahard, Dulce Alfaiate, Firouzé Bani‐Sadr, Laurent Hocqueloux, David Rey, Catherine Chirouze, F Bozon, Laurent Hustache‐Mathieu, J Lagoutte, S Marty-Quinternet, Line Pépin‐Puget, B. Rosolen, Nadine Tissot, Corinne Lebreton, Louis Bohard, S. Jaffuel, Séverine Ansart, Y Quintric, Schéhérazade Rezig, Luc Quaesaet, Pierre Gazeau, Christine Jacomet, Christian Theis, C Richaud, A Benelhadj, Aida Zaghdoudi, M Berthommier, Macarthur Charles, Claire Durand, Dilek Çoban, A Mirand, A Brebion, Hélène Chabrolles, Ophélie Perruche, Elisa Creuzet, Cécile Henquell, G Baronnet, François Bissuel, F Boulard, Arnaud Chéret, Julien Coussement, E Curlier, Tanguy Dequidt, C Desfontaines, Sandra Devatine, E Duvallon, C Herrmann-Storck, Cécile Loraux, Samuel Markowicz, Magda Marquet, Rachida Ouissa, Sandrine Peugny, L Pradat-Paz, M Receveur, J Reltien, K Samar, Kinda Schepers, B. Tressières, V Walte, Dominique Merrien, O Bollangier, D Boucher, T Guimard, L Laine, S Léautez, Marine Morrier, P Perré, Mariam Roncato-Sabéran, Xavier Pouget-Abadie, C Chapuzet, A. W. Thomas, Jean‐François Faucher, A. Cypierre, S. Ducroix-Roubertou, H. Durox, C Genet-Villeger, J.C. Pascual, P. Pinet, Cyrielle Codde, C Benoist, Sarah Mafi, A Becker, Matthieu Godinot, Florence Ader, E Braun, Céline Brochier‐Armanet, Florence Brunel-Dalmas, Pierre Chiarello, Andrew Conrad, S Degroodt, Pascal Fascia, Tristan Ferry, V. Guéripel, V Icard, Jason Izard, Clément Javaux, H Lardot, John Lippmann, Djamila Makhloufi, Yassine Merad, T Perpoint, S Roux, S Sahyouni, Maria S. Simon, Mary‐Anne Trabaud, Claire Triffault-Fillit, F Valour, Ana Batalla, Lorena van den Bogaart, A Ménard, Y Belkhir, Philippe Colson, C Dhiver, M Martin-Degioanni, A Motte, C Toméi, Matthieu Million, N De Palmas, M Champeaux, Isabelle Ravaux, Sylvie Brégigeon, O Zaegel-Faucher, H Laroche, M J Ducassou, A Ivanova, I Jaquet, V. Obry‐Roguet, M Orticoni, E. Ressiot, A S Ritleng, F Niemetzky, C Ferron, Sylvie Abel, Ornella Cabras, L Cuzin, Georges Dos Santos, L. Facelina, Laurence Fagour, L. de Ghellinck, K Guitteaud, E Louis-Michel, Elena Medo, Fanny Quénard, Pierre-Yves Richard, Allan Schapira, B Tregan, Claire Robert, Zoé Cavalli, L Bucy, Arthur M. Fournier, A Makinson, Agathe Artiaga, M Bistoquet, V Le Moing, J.-P. Lejeune, Laurent Perez, Nathalie Pansu, C Tramoni, Benjamin Lefèvre, S Bevilacqua, Mélodie Grandin, Alexandre Charmillon, E. Frentiu, François Goehringer, Sandrine Hénard, Eliette Jeanmaire, C Rabaud, Lucas Lalevée, Jeanne Kotzyba, Antoine Asquier-Khati, Vinícius de Aguiar Bellon, E Billaud, Sabelline Bouchez, David Boutoille, C Brunet-Cartier, M Cavellec, Lio Collias, C Deschanvres, Thomas Drumel, Benjamin Gaborit, Matthieu Grégoire, T Jovelin, Anne‐Marie Lefebvre, R. Lecomte, R Mahot, Cécile Mear-Passard, Camille Moyon, E. Paredes, G Querne, Pascal Puglièse, S Bréaud, Matthieu Buscot, M Carles, Johan Courjon, Anne De Monte, J Durant, Stephen J. Ferrando, I Perbost, B Prouvost-Keller, K Risso, I Touitou, A Viot, S Wehrlen-Pugliese, Shyam Sunder, Véronique Goudet, Andrey Santos, V Rzepecki, L Hocqueloux, Richard Albert, V. Avettand-Fenoel, Sandrine Bafong-Ketchemen, Guillaume Béraud, J Effa, C. Gubavu, Vincent Legros, Gilbert Mchantaf, Catherine Mille, Youssouf Mohamed-Kassim, A Sève, L. Vitry d'aubigny, C Goujard, A Castro-Gordon, P David-Chevallier, V Godard, Yann Quertainmont, E Teicher, Stéphane Jauréguiberry, L. Escaut, Mélanie Cresta, E. Oliosi, C. Couzigou, Ouda Derradji, Rocco Collarino, Y Liotier, M Merad, E Zamparini, Julie Bottero, V Joly, C. Charpentier, M Digumber, A Gervais, Jade Ghosn, Zélie Julia, Roland Landman, S Le Gac, F Louni, Nathan Peiffer‐Smadja, C. Rioux, Y Yazdanpanah, Laurène Deconinck, C Duvivier, Ghania Benabdelmoumen, G Cessot, Massimiliano Garzaro, E Gomes-Pires, Patrick Hochedez, Oula Itani, Emmanuel Lafont, Fanny Lanternier, Olivier Lortholary, J Lourenco, Cléa Melenotte, P Parize, C. Rouzaud, Alexandra Serris, F Taieb, Jérémy Zeggagh, M. A. Valantin, Christine Katlama, L Schneider, Sophie Seang, R Tubiana, Antoine Fayçal, Sanaa Saliba, Marion Favier, Cécile Aubron, Rachid Agher, Yasmine Dudoit, N Hamani, N Qatib, Aziza Chermak, M Chansombat, G Osseni, D. Beniken, A Nadour, Pascale Perfezou, J C Duthé, F B Drevillon, Jean‐Philippe Talarmin, L. Khatchatourian, Paul Petitgas, F Bani-Sadr, Véronique Brodard, Maxime Hentzien, I Kmiec, D Lambert, D. Lebrun, Marin Moutel, A Brunet, H Marty, Yohan N’Guyen, C Arvieux, M Baldeyrou, M. Cailleaux, J M Chapplain, A Lebot, David Luque-Paz, Anne Maillard, Clément Morlat, S. Patrat-Delon, L Picard, M Poisson-Vannier, Michel Sébillotte, P Tattevin, J Vivent, Élisabeth Botelho-Nevers, Anne Pouvaret, F. Saunier, C Bernard-Henry, Pierre Gantner, C Mélounou, Philippe Klee, Y. Hansmann, Nicolas Lefèbvre, Yvon Ruch, Baptiste Hoellinger, T. Lemmet, Vinzenz Gerber, J M Schevin, Alexandra Fuchs, Coralie Le Hyaric, Diego Rey, Marco Antonio Álvarez, X. Boumaza, Akihiro C. Ko, Nived Collercandy, Cyrille Delpierre, Peggy Gandia, Camille Garnier, Romain Gueneau, L Lelièvre, C Rastoll, Stéphanie Raymond, Camille Vellas, O Robineau, E Aïssi, I Alcaraz, Enagnon Kazali Alidjinou, Anne Boucher, Vincent Derdour, B. Lafon-Desmurs, A Meybeck, M Pradier, Macha Tétart, M Valette, N Viget, Ayouba Diarra, E Bontemps, Grégory Corvaisier, M. Brière, M. de la Chapelle, Marie Gousseff, Rémi Nguyen Van, M. Thierry
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Résumé fourni par la source
Abstract Background People with HIV (PWH) are at higher risk of developing chronic hepatitis B, and therefore vaccination against HBV is highly recommended. Clearance of hepatitis B surface antibody (anti-HBs) over time is poorly described in PWH. Methods We retrospectively included vaccinated PWH with anti-HBs ≥10 IU/L from the French Dat’AIDS database. Those with a cured hepatitis B were excluded. For each participant, all anti-HBs levels were collected until March 2024. Anti-HBs peak was defined as the highest anti-HBs value and corresponded to entry into the analysis. Factors associated with anti-HBs clearance below 10 IU/L were identified using a multivariable Cox model. Results 11 082 PWH were included, 4480 had peak anti-HBs levels between 10 and 99 IU/L, 3268 between 100 and 499 IU/L, 1205 between 500 and 999 IU/L, and 2129 ≥ 1000 IU/L. Median follow-up was 3.8 [1.6, 7.1] years. Antibody clearance over time was similar in the three groups with peak anti-HBs ≥100 IU/L, and significantly slower than in the group with anti-HBs <100 IU/L. Peak anti-HBs level was the variable with the greatest impact on anti-HBs clearance in the multivariable analysis. Compared with participants with anti-HBs <100 IU/L, having peak anti-HBs values of 100–499 IU/L, 500–999 IU/L and ≥1000 IU/L were protective factors for anti-HBs clearance, with hazard ratios of .26 [0.23, 0.30], 0.17 [0.13, 0.22] and 0.10 [0.07, 0.12], respectively, P < .001. Conclusions Peak anti-HBs level is the key factor of antibody persistence in PWH. Those with anti-HBs levels below 100 IU/L should be monitored closely and considered for a booster dose.
Sujets associés
Hepatitis B Virus StudiesHepatitis Viruses Studies and EpidemiologyHepatitis C virus research