CD9-positive tumor-associated macrophages promote renal cell carcinoma progression by activating the orphan nuclear receptor Nor1/Nr4a3
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Le résumé fourni par la source
Tumor growth, metastasis, and treatment response in renal cell carcinoma (RCC) are believed to be regulated by the tumor microenvironment (TME). However, the mechanisms underlying the genomic, transcriptomic, and epigenetic alterations in clear cell RCC progression remain incompletely understood. This study analyzed single-cell RNA sequencing data from public databases, including tissue samples from three patients with RCC and three matched pairs of immune cells from tumor tissue and peripheral blood to screen macrophages with differential expression in the TME. We found that a CD9 + macrophage population was identified in the RCC tumor tissue, suggesting a role for CD9-expressing macrophages in RCC progression. The function of these macrophages was further investigated through in vitro and in vivo experiments involving CD9 knockdown or overexpression. CD9 expression was elevated in RCC tissues compared to adjacent non-cancerous tissues. CD9 knockdown considerably inhibited the TME-induced macrophages (M2), while CD9-overexpressing macrophages markedly promoted RCC cell growth in vitro and in vivo. Moreover, this phenomenon may be associated with the orphan nuclear receptor NOR1//Nr4a3 activation by CD9. These findings indicated that macrophages in the TME exhibited distinct expression patterns during RCC progression and that CD9 + macrophages promoted RCC development, suggesting that CD9 may be a potential therapeutic target for inhibiting RCC progression.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- CD9-positive tumor-associated macrophages promote renal cell carcinoma progression by activating the orphan nuclear receptor Nor1/Nr4a3
- Date Crossref
- 12/12/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Liaoning University of Traditional Chinese Medicine Department of Integrated Traditional Chinese and Western Medicine pays non établi dans la noticeUniversité ou école supérieure
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Dalian Medical University Department of Clinical Laboratory Medicine pays non établi dans la noticeUniversité ou école supérieure
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First Affiliated Hospital of Dalian Medical University pays non établi dans la noticeÉtablissement de santé
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Shenyang Medical College Department of Dermatovenereology pays non établi dans la noticeUniversité ou école supérieure
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Guangdong Medical College pays non établi dans la noticeUniversité ou école supérieure
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Key Laboratory of Guangdong Province pays non établi dans la noticeStructure de recherche
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Beijing University of Technology pays non établi dans la noticeUniversité ou école supérieure
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China Agricultural University pays non établi dans la noticeUniversité ou école supérieure
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Peking University pays non établi dans la noticeUniversité ou école supérieure
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China Medical University Department of Family Medicine pays non établi dans la noticeUniversité ou école supérieure
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First Hospital of China Medical University pays non établi dans la noticeÉtablissement de santé
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Affiliated Hospital of Guangdong Medical University Department of Nephrology pays non établi dans la noticeUniversité ou école supérieure
Department of Integrated Traditional Chinese and Western Medicine — Liaoning University of Traditional Chinese Medicine, Department of Clinical Laboratory Medicine — Dalian Medical University et First Affiliated Hospital of Dalian Medical University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.