Molecular and Microbial Remodeling in Response to Vestibular System Stress at Sea

Le résumé fourni par la source

The vestibular system contributes to our sense of proprioception and equilibrium, interacting with all body systems through projections to different brain areas. However, the molecular consequences of vestibular disturbance remain unclear. Here, we performed longitudinal multiomics analyses of urine, stool, and saliva from 3 cohorts participating in ocean voyages and their corresponding counterparts who remained on land. On board, proteins involved in the vestibulo-ocular reflex and musculoskeletal systems were down-regulated, and the endocrine and cardiovascular systems exhibited potentially detrimental alterations. Neuronal ephrin receptors and proteins in the endolysosomal system were down-regulated, whereas neuroprotective and neurometabolic processes were up-regulated. Remodeling of the neuronal and immune systems altered host–microbial interactions, reducing neurotransmitter–bacteria associations, suppressing bacteria–host cometabolism, and reducing the Prevotella abundance. Participants in the smaller vessel exhibited more pronounced neuronal and immune alterations. Furthermore, compared with non-seasick individuals, seasick individuals presented lower levels of endolysosomal proteins and a higher Prevotella abundance. This study provides a valuable resource for understanding the transition from living on land to living on the ocean and vestibular stress-related molecular changes.

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