Baccharis dracunculifolia DC (“Alecrim do campo”) nanoemulsion fails to modulate inflammation in mice under a high-sodium diet

Le résumé fourni par la source

High sodium intake can disrupt the tissue sodium balance and inflammatory responses, potentially impairing wound healing.Natural plant extracts may facilitate tissue repair by modulating inflammation, however, their therapeutic potential remains underexplored.This study evaluated the impact of a high sodium diet (HSD) on cutaneous inflammation induced by subcutaneously implanted non-biocompatible sponges and evaluated the anti-inflammatory potential of Baccharis dracunculifolia (DC) extract formulated in a nanoemulsion (nDC).Weaned male Wistar rats were fed either a high sodium diet (HSD; 0.90% Na⁺, w/w) or a standard-sodium diet (SSD; 0.27% Na⁺, w/w) for 12 weeks (n = 16 per group).Sponges were then implanted, and the animals received oral treatment with 50 mg/kg nDC or vehicle (unloaded nanoemulsion) once daily for 14 days while continuing their respective diets.After treatment, sponges were collected for evaluation of cellular infiltration, vessel density, myeloperoxidase (MPO) and N-acetyl-β-D-glucosaminidase (NAG) activities, and histopathology.No significant differences in inflammatory cell counts, vessel density, or MPO and NAG activities were observed between the HSD and SSD animals under any treatment condition (p > 0.05).Histology revealed dense inflammatory infiltrates in all groups.These findings indicate that HSD did not exacerbate inflammation in all groups.These results indicate that HSD did not exacerbate inflammation in this model, and nDC treatment did not modulate inflammatory responses.In conclusion, neither HSD nor nDC influenced inflammatory cell recruitment in the murine wound healing model.

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