Identification of genetic determinants that drive population differentiation and host adaptation in Campylobacter jejuni in California
Rattachement africain : gb, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Campylobacter jejuni is a commensal bacterium that colonizes livestock and wild animals and is responsible for more than 80% of campylobacteriosis cases in humans, which all ultimately have an animal source. Its high genome plasticity and recombination rate allow it to adapt to multiple hosts and lead to the rapid emergence of lineages, some of which can be antibiotic resistant. Our aim in this study was to examine the population structure of Campylobacter in California and assess its differentiation between animal hosts and humans. We sequenced 69 human clinical isolates of C. jejuni from California and collected a dataset of human and animal Californian genomes to contextualize them. By comparing groups of isolates, we detected significant levels of differentiation between the human and animal Californian isolates. Through phylogenetic reconstruction, we demonstrated that, as expected, the human C. jejuni clinical isolates were derived from both avian and ruminant sources but represented a distinct subset of those populations. By identifying the genomic regions that were contributing to population differentiation amongst the host groups, we were able to identify protein variants potentially responsible for host adaptation and propensity to cause infection in humans.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Identification of genetic determinants that drive population differentiation and host adaptation in Campylobacter jejuni in California
- Date Crossref
- 08/12/2025
- Éditeur
- Microbiology Society
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Cambridge Department of Veterinary Medicine pays non établi dans la noticeUniversité ou école supérieure
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University of Oxford Department of Biology pays non établi dans la noticeUniversité ou école supérieure
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Milken Institute Department of Environmental and Occupational Health pays non établi dans la noticeOrganisation à but non lucratif
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George Washington University pays non établi dans la noticeUniversité ou école supérieure
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Kaiser Permanente pays non établi dans la noticeOrganisation à but non lucratif
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Public Policy Institute of California pays non établi dans la noticeOrganisation à but non lucratif
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Johns Hopkins University pays non établi dans la noticeUniversité ou école supérieure
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Department of Research & Evaluation pays non établi dans la noticeInstitution
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Bloomberg School of Public Health Center for a Liveable Future pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins Risk Sciences and Public Policy Institute pays non établi dans la noticeStructure de recherche
Department of Veterinary Medicine — University of Cambridge, Department of Biology — University of Oxford et Department of Environmental and Occupational Health — Milken Institute, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.