Effect of ozone therapy on post-operative pain following mandibular third molar surgical extraction: a split-mouth randomized clinical trial
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Le résumé fourni par la source
OBJECTIVES: To evaluate the efficacy of ozone therapy on pain reduction, trisma and number of analgesic tablets taken following surgical removal of impacted mandibular third molar. METHODS: A split-mouth randomized clinical trial was conducted in 54 patients in need of bilateral impacted mandibular third molars (Pell-Gregory class II-B) extraction. Test sites were treated with adjunctive ozone therapy to the surgical extraction, while controls underwent surgical intervention only (time between surgeries: 3 weeks). Study primary outcome measure was the difference in perceived pain recorded using a Numerical Rating Scale (NRS) at 7 days after surgery. In addition, functional limitation in mouth opening (mm), number of analgesic tablets taken within one week after surgery as well as the patient's perceived quality of life (Oral Health Impact Profile (OHIP-14) were evaluated. RESULTS: Fifty patients (20 males and 30 females; median age: 21 years; all non-smokers) completed the study. Mean reported perceived pain decrease from 5.06 to 0.58 (test group) and from 5.62 to 1.08 (control group) between day 1 and 7. No statistically significant differences were detected between the two groups at any time points (p > 0.05). At day 7, mean mouth opening value was 40.8 vs. 36.6 mm in test and control group respectively (mean difference: 4.24 mm; p < 0.001; 95% CI: 6.55-1.93). The same trend was detected for the of number of analgesic tablets taken (median: 4 vs. 7; p = 0.01). Finally, OHIP-14 values did not differ between groups (p > 0.05). CONCLUSION: Ozone therapy had a beneficial clinical effect in terms of mouth opening and in the number of analgesic tablets intake at 7 days after surgical removal of impacted mandibular third molar, despite the lack of adjunctive benefit on patients perceived pain reduction. CLINICAL RELEVANCE: The clinical use of ozone therapy as adjunct to surgical removal of impacted mandibular third molar might be considered in light of the promising positive reported results in terms of mouth opening reduction and analgesic intake. CLINICAL TRIAL REGISTRATION NUMBER: NCT05949476.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Effect of ozone therapy on post-operative pain following mandibular third molar surgical extraction: a split-mouth randomized clinical trial
- Date Crossref
- 09/12/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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A. O. Ordine Mauriziano di Torino pays non établi dans la noticeÉtablissement de santé
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Policlinico Umberto I pays non établi dans la noticeÉtablissement de santé
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University of Turin pays non établi dans la noticeUniversité ou école supérieure
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University of Bern pays non établi dans la noticeUniversité ou école supérieure
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Shanghai Ninth People's Hospital pays non établi dans la noticeÉtablissement de santé
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Mauriziano Umberto I Hospital Department of Dentistry and Oral Surgery pays non établi dans la noticeÉtablissement de santé
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Clinical Trial Unit pays non établi dans la noticeÉtablissement de santé
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University of Torino Division of Maxillofacial Surgery pays non établi dans la noticeUniversité ou école supérieure
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College of Stomatology pays non établi dans la noticeUniversité ou école supérieure
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School of Dental Medicine Department of Periodontology pays non établi dans la noticeUniversité ou école supérieure
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Shanghai Jiao Tong University School of Medicine Institute for Integrated Oral pays non établi dans la noticeUniversité ou école supérieure
A. O. Ordine Mauriziano di Torino, Policlinico Umberto I et University of Turin, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.