Noninvasive assessment of oxidative stress in pelvic organ prolapse: a feasibility study
Rattachement africain : cz. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Pelvic organ prolapse (POP) is increasingly relevant in aging populations. Oxidative stress (OS) may weaken pelvic support structures, but previous studies relied on invasive tissue sampling, limiting longitudinal use. This study evaluated whether OS markers can be detected non-invasively in vaginal fluid and whether they correlate with POP severity. We prospectively enrolled 160 women with POP between February 2021 and June 2023. Vaginal fluid samples were collected, and three OS markers: 8-hydroxy-2′-deoxyguanosine (8-OHdG), 4-hydroxynonenal (HNE), and advanced glycation end products (AGE) were quantified using commercial ELISA kits. POP severity was assessed by POP-Q and ultrasound parameters. 8-OHdG was consistently detectable and significantly elevated in advanced POP compared to early stages (p = 0.001), showing a modest positive correlation with prolapse severity (ρ = 0.24, p < 0.001). Regression analysis confirmed 8-OHdG as an independent predictor of prolapse severity (R2 = 0.964). AGE levels did not differ significantly between groups, and HNE values were below detection thresholds in most samples. No associations were found between OS markers and age, BMI, or menopause duration. Non-invasive assessment of oxidative stress in vaginal fluid is feasible. Elevated 8-OHdG correlates with POP severity, supporting its potential as a biomarker for disease monitoring and future translational research.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Noninvasive assessment of oxidative stress in pelvic organ prolapse: a feasibility study
- Date Crossref
- 08/12/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University Hospital Hradec Králové Department of Obstetrics and Gynecology pays non établi dans la noticeOrganisme public
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University of Hradec Králové Institute for Primary pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine in Hradec Kralove Department of Obstetrics and Gynecology pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Informatics and Management Department of Informatics and Quantitative Methods pays non établi dans la noticeUniversité ou école supérieure
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Department of Gynecology and Obstetrics pays non établi dans la noticeInstitution
Department of Obstetrics and Gynecology — University Hospital Hradec Králové, Institute for Primary — University of Hradec Králové et Department of Obstetrics and Gynecology — Faculty of Medicine in Hradec Kralove, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.