Genome-sequencing of ocular fluid in a patient with syphilitic uveitis: Strain identification and antimicrobial resistance detection

Le résumé fourni par la source

Purpose: To describe an unusual case of bilateral, hypertensive uveitis in which a syphilis genome with antimicrobial resistance was identified in the aqueous humor. Methods: A retrospective review of patient records was performed for clinical data. An aqueous humor sample was collected, and syphilis genomes were analyzed for phylogenetic traits and antimicrobial resistance. Results: species, which showed the Nichols lineage with macrolide resistance. The patient responded favorably to penicillin therapy with resolution of syphilitic uveitis and improvement in visual acuity. Conclusions and importance: This case report highlights the utility of ocular fluid's genome sequencing in diagnosing ocular syphilis and detecting antimicrobial resistance. Given the resurgence of syphilis in the U.S. and globally and the shortage of penicillin worldwide, genomic sequencing of ocular fluid may also assist in antimicrobial resistance detection for syphilis, along with pathogen identification, in concert with serologic assessment.

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