Differential alpha-gal expression during Amblyomma hebraeum and Rhipicephalus evertsi tick feeding and development: A driver for the development of alpha-gal syndrome in South Africa

Résumé fourni par la source

Background: The presence of galactose-α-1,3-galactose (alpha-gal) in tick salivary antigens has been implicated to initiate host IgE responses resulting in sensitization to alpha-gal. Objective: We sought to investigate the presence of alpha-gal in different anatomic locations in native South African tick species at different feeding and developmental stages and the ability of sera from our allergic cohort to bind to these tick proteins. Methods: Alpha-gal-containing proteins in laboratory-reared ticks at different feeding and developmental stages were detected through Western blotting and immunohistochemical staining. IgE and IgG4 toward the tick proteins were analyzed via ELISA. Results: proteins was significantly reduced by the addition of bovine thyroglobulin. Conclusions: alpha-gal-containing salivary proteins during feeding to cause alpha-gal sensitization.

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