YAP-induced MAML1 cooperates with STAT3 to drive hepatocellular carcinoma progression
Rattachement africain : cn, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Hepatocellular carcinoma (HCC) is a major liver malignancy and a leading cause of cancer-related mortality worldwide. Given its rising incidence and poor prognosis, there is an urgent need to elucidate the molecular mechanisms driving HCC progression and to develop novel targeted therapies. In this study, we identify MAML1 as a key contributor to HCC development. Elevated MAML1 expression strongly correlated with disease severity, whereas its knockdown suppressed HCC progression. Functionally, MAML1 promoted tumor malignancy by regulating STAT3 activity. Mechanistically, MAML1 interacted with STAT3 and enhanced its acetylation in a p300-dependent manner. Inhibition of STAT3 with a specific inhibitor attenuated MAML1-driven HCC progression. Furthermore, signaling pathway analyses revealed that YAP is the principal transcription factor regulating MAML1 expression by directly binding its promoter. Importantly, depletion of MAML1 diminished YAP-induced HCC malignancy and STAT3 activation, suggesting that YAP, MAML1, and STAT3 form a coordinated signaling axis that drives HCC progression. Collectively, these findings uncover a novel MAML1-centered signaling pathway in HCC and provide a compelling rationale for the development of MAML1-targeted clinical strategies for disease management.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- YAP-induced MAML1 cooperates with STAT3 to drive hepatocellular carcinoma progression
- Date Crossref
- 05/12/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Central South University Department of General Surgery pays non établi dans la noticeUniversité ou école supérieure
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Xiangya Hospital Central South University pays non établi dans la noticeÉtablissement de santé
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Southwest Medical University pays non établi dans la noticeÉtablissement de santé
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National Clinical Research pays non établi dans la noticeStructure de recherche
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International Joint Research Center of Minimally Invasive Endoscopic Technology Equipment & Standards pays non établi dans la noticeStructure de recherche
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School of Basic Medical Sciences Department of Biochemistry and Molecular Biology pays non établi dans la noticeUniversité ou école supérieure
Department of General Surgery — Central South University, Xiangya Hospital Central South University et Southwest Medical University, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.