Dengue and endothelium: a perspective on the pathophysiological implications of endothelial activation in dengue and its therapeutic possibilities

Le résumé fourni par la source

Introduction: Dengue is a widely spread viral febrile illness, with nearly half of the world’s population, approximately four billion people, living in areas at risk of dengue infection. It is often the leading cause of illness in these high-risk areas. Dengue is caused by four virus serotypes (Dengue 1, Dengue 2, Dengue 3, and Dengue 4). This virus is transmitted through the bites of infected female mosquitoes, primarily Aedes aegypti and Aedes albopictus. There is no specific medication to treat dengue, the and current management of the disease is symptomatic. Thus, an urgent search for specific therapeutic alternatives targeting the virus or the pathophysiological mechanisms responsible for severe forms of the disease is critical. The aim was to gather experimental evidence on the significance of endothelial activation in the pathophysiology of dengue, as available in the scientific literature. Materials and methods: A literatura search were conducted in English using the PubMed, Scopus, and ScienceDirect databases with the keywords dengue, endothelium, pathophysiology, and endothelial activation. Results: Experimental evidence has shown that endothelial dysfunction is central to the clinical manifestations of severe dengue. Discussion: The identification of pathophysiological mechanisms at the endotelial cell level has revealed numerous therapeutic targets for dengue, which need to be validated through clinical studies.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.