Prevalence of schistosome infection among children under two years of age: a brief report from medium-to-high endemic regions of Schistosoma mansoni in Madagascar
Rattachement africain : de, Madagascar, nl. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
INTRODUCTION: Schistosome infections in early childhood can affect a child's growth and development, leading to lifelong consequences. Historically, monitoring and control of schistosomiasis have focused primarily on school-aged children leading to a knowledge gap on the magnitude of the prevalence of infections in younger age groups in many endemic countries. This study aimed to estimate the prevalence of schistosome infections among children under 2 years of age and describe its distribution in three regions of Madagascar endemic for Schistosoma mansoni, thereby informing public health strategies in the country. METHODS: A cross-sectional study was conducted on a sample of 2018 children under 2 years of age recruited from 42 primary health care centres in the regions of Itasy, Bongolava and Amoron'i Mania, Madagascar, from March 2020 to June 2021. Urine samples were collected to perform an up-converting reporter particle lateral flow circulating anodic antigen assay (UCP-LF-CAA) for the detection of schistosome infections. To identify factors associated with the prevalence of schistosome infection, prevalence ratios with 95% CIs were estimated using mixed-effects Poisson regression. RESULTS: Among 2018 sampled children with an average age of 9.6 months (SD = 1.2), the prevalence of schistosome infection was 6.2% [CI95%: 5.0, 7.8]. The prevalence estimates were similar across all population subgroups. We observed no statistically significant associations of schistosome infections in children with maternal age (p-value = 0.4110), education (p-value = 0.1281), occupation (p-value = 0.3333), child sex (p-value = 0.3692), urbanisation (p-value = 0.8272) or region of residence (p-value = 0.7425). CONCLUSION: Our results show that the prevalence of schistosome infection in children under 2 years of age in Madagascar is significant. Given the high burden and long-term consequences of early schistosome infection, integrated and inclusive public health interventions that combine treatment, caregiver health education, with improvements in sanitation and access to clean water, are needed for children under 2 years of age in endemic settings.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Prevalence of schistosome infection among children under two years of age: a brief report from medium-to-high endemic regions of Schistosoma mansoni in Madagascar
- Date Crossref
- 04/12/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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German Center for Infection Research pays non établi dans la noticeStructure de recherche
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Bernhard Nocht Institute for Tropical Medicine Department of Infectious Diseases Epidemiology pays non établi dans la noticeStructure de recherche
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Université de Fianarantsoa Université de Fianarantsoa, Madagascar (code pays fourni par la source)Université ou école supérieure
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University of Antananarivo University of Antananarivo, Madagascar (code pays fourni par la source)Université ou école supérieure
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Leiden University Medical Center Center for Infectious Diseases pays non établi dans la noticeOrganisme public
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Association Promotion de la Santé Fianarantsoa, Madagascar (pays nommé en fin d’affiliation)Organisation à but non lucratif
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University Hospital Tambohobe Infectious Diseases Service Fianarantsoa, Madagascar (pays nommé en fin d’affiliation)Université ou école supérieure
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Centre d'Infectiolologie Charles Mérieux (CICM) Antananarivo, Madagascar (pays nommé en fin d’affiliation)Institution
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University Antananarivo University Antananarivo, Madagascar (pays nommé en fin d’affiliation)Université ou école supérieure
German Center for Infection Research, Department of Infectious Diseases Epidemiology — Bernhard Nocht Institute for Tropical Medicine et Université de Fianarantsoa (Université de Fianarantsoa, Madagascar), avec 6 autres affiliations. Pays d’affiliation : Madagascar.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.