Inflammatory Bowel Disease and Mental Health: The Complex Relationship Between Gut and Brain
Rattachement africain : pk, ie, gb. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: The study sought to determine the association between IBD severity and mental health impact as measured by anxiety, depression, and QOL in our Pakistani patients. DESIGN AND METHODS: A cross-sectional study was conducted with 400 IBD patients from clinics and community healthcare centres in Faisalabad, Dera Ismail Khan, and Karachi. Data were collected using the Short IBD Questionnaire (SIBDQ) and Hospital Anxiety and Depression Scale (HADS). Spearman correlations, chi-square tests, Mann-Whitney U, Kruskal-Wallis, and multiple regression analyses (SPSS v26) were performed. RESULTS: Of 400 participants, 240 (60%) were female, and most were aged 25-34 years (126, 31%). A total of 190 (47%) scored ≥11 on the HADS, indicating clinically significant anxiety or depression. SIBDQ and HADS scores were negatively correlated (ρ = -0.33, 95% CI -0.40 to -0.26, p < 0.001). Multiple regression showed that higher HADS scores were predicted by greater disease severity (B = 0.19, 95% CI 0.08-0.29, p = 0.001), female gender (B = 0.89, 95% CI 0.25-1.53, p = 0.007), younger age (B = -0.21, 95% CI -0.37 to -0.05, p = 0.011), disease activity (B = 0.44, 95% CI 0.14-0.74, p = 0.004), IBD type (B = 0.53, 95% CI 0.16-0.90, p = 0.006), and family history (B = 0.69, 95% CI 0.08-1.30, p = 0.026). Patients with severe IBD had the highest rates of clinically significant anxiety or depression (62% vs 43% in moderate and 10% in normal; χ²(4) = 81.9, p < 0.001). Females and younger participants reported greater disease severity and mental health burden (p < 0.01). CONCLUSIONS: Anxiety and depression are prevalent among Pakistani IBD patients, particularly in women, younger adults, and those with severe disease. These findings highlight the need for integrated gastroenterology-psychiatry care with routine mental health screening and psychosocial support to improve long-term outcomes and quality of life.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Inflammatory Bowel Disease and Mental Health: The Complex Relationship Between Gut and Brain
- Date Crossref
- 03/12/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Punjab Medical College pays non établi dans la noticeUniversité ou école supérieure
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Cork University Hospital Internal Medicine pays non établi dans la noticeÉtablissement de santé
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Gomal University pays non établi dans la noticeUniversité ou école supérieure
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Aberdeen Royal Infirmary Gastroenterology pays non établi dans la noticeÉtablissement de santé
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Scarborough General Hospital Internal Medicine pays non établi dans la noticeÉtablissement de santé
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Liaquat University of Medical & Health Sciences pays non établi dans la noticeUniversité ou école supérieure
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Faisalabad Medical University Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
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Gomal Medical College Gastroenterology pays non établi dans la noticeUniversité ou école supérieure
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Liaquat University of Medical and Health Sciences Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
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York and Scarborough Teaching Hospitals NHS Foundation Trust Internal Medicine pays non établi dans la noticeÉtablissement de santé
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York and Scarborough Teaching Hospitals HNS Foundation Trust Internal Medicine pays non établi dans la noticeÉtablissement de santé
Punjab Medical College, Internal Medicine — Cork University Hospital et Gomal University, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.