ENT Infections and Skin Infections Due to Streptococcus pyogenes: Prevalence and Antibiotic Sensitivity Profile of Strains Isolated at Albert Royer Children’s Hospital, Dakar-Senegal

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Background: Streptococcus pyogenes or Groupe A Streptococcus (GAS) infections constitute a real public health problem due to their frequency and the post-infectious complications they cause. Thus, it is necessary to update epidemiological data for better management. This study aimed to determine the prevalence of GAS in skin and ENT infections and to study their antibiotic susceptibility profile. Methods: It was a prospective study of Streptococcus pyogenes skin and ENT infections at Albert Royer Children’s Hospital. Bacterial isolation and identification were performed using standard bacteriological techniques. Data were entered using Excel 2010 software and analyzed using Epi info 7.2 software. Results: A total of 245 patients were included, with a mean age of 5.49 years and a standard deviation of 3.9. The proportion of male patients was higher (51%), and the majority were aged from 0 to 3 years. The prevalence of GAS infection was 6.93%. Streptococcus pyogenes strains had good susceptibility to penicillin G (100%), cefotaxime (100%), ceftriaxone (100%), ceftazidime (100%), chloramphenicol, and vancomycin (100%). The activity of erythromycin was good (87%), as well as that of ampicillin (86%), lincomycin (75%), rifampicin (71%) and pefloxacin (67%). However, poor activity was noted for cotrimoxazole (43%), norfloxacin (33%) and resistance to all strains for gentamicin. Conclusion: The prevalence of Streptococcus pyogenes infections was low. Antibiotic susceptibility was variable. Penicillin G, cefotaxime, ceftriaxone, ceftazidime, chloramphenicol, and vancomycin had very good activity. However, the activity of cotrimoxazole, norfloxacin, and gentamicin was low.

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