Randomized Trial Evaluating a Tailored eHealth Intervention for Symptom Management in Couples Managing Prostate Cancer During the COVID-19 Pandemic (Preprint)

Résumé fourni par la source

UNSTRUCTURED Background: This randomized controlled trial evaluated the efficacy of the “Prostate Cancer (PCa) Education & Resources for Couples” (PERC) eHealth intervention to improving the outcomes for patients and their partners. Methods: We enrolled 280 dyads (560 individuals) of patients with localized PCa who recently completed treatment, and their partners. Dyads were randomized to PERC or a control group who accessed an an NCI PCa website. Validated questionnaires assessed quality of life (QOL, FACT-G total; primary outcomes) and FACT-G subdomains, symptom and psychosocial measures (secondary outcomes) at baseline and 4, 8, and 12 months (T1-T4). Multilevel linear mixed models tested intervention effects. Results: FACT-G total, subdomain, and overall overall psychosocial outcomes did not differ significantly between groups over time. PERC patients reported marginally higher physical QOL (95% CI: –0.1 to 1.9, d=0.33), better illness appraisal (95% CI: 0.0 to 0.4, d=0.38), lower pain (95% CI: –5.3 to –0.2, d=0.38) at T4, and less frequent fatigue across time (95% CI: –3.9 to –0.4). PERC partners reported less urinary symptom bother at T3 (95% CI: -1.0 to14.1, d=0.44). Discussion: PERC demonstrated exploratory benefits including patients’ improved physical QOL, less fatigue, lower pain, improved illness appraisal in patients, and less urinary bother in partners.

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