Psychosocial stressors as modifiers of the associations between well-studied and understudied chemicals and birth outcomes in the ECHO Cohort
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Le résumé fourni par la source
Psychosocial stressors may exacerbate observed associations between environmental toxicants and adverse birth outcomes. However, studies have primarily focused on well-known compounds rather than a broader range of chemicals of concern. Pregnant women in this analysis had a prenatal urine sample analyzed for 113 well-studied and understudied chemical analytes, and at least one measure of psychosocial stress (N=1,566). We measured analytes from 10 chemical classes, including fungicides/herbicides, insecticides, halogenated phenols, organophosphorus flame retardants, benzophenones, bisphenols, parabens, antimicrobials, phthalates/alternative plasticizers, and polycyclic aromatic hydrocarbons. Principal component analysis was used to identify clusters of exposure patterns. Generalized Estimating Equation models assessed associations between principal components (PCs) and molar sums of each chemical class with birthweight z-scores and gestational age at birth, stratified by individual stressors (i.e., categorical adverse childhood experiences [ACEs; 0, 1-2, and 3-5]; binary prenatal perceived stress, depression, and anxiety). The PC reflecting higher exposure to all analytes (PC1) was negatively associated with birthweight z-scores only among those who experienced 3-5 ACEs compared with those with no ACEs (β PC1 =-0.08, 95% confidence interval [CI]=-0.11, -0.05 for 3-5 ACEs; β PC1 =-0.01, 95% CI=-0.05, 0.04 for 0 ACEs). Most phthalate molar sums were inversely associated with gestational age only among those with anxiety during pregnancy (e.g., β DINP =-0.29, 95% CI=-0.41, -0.18 for anxiety-yes; β DINP = 0.23, 95% CI=0.01, 0.46 for anxiety-no). Findings suggest that certain psychosocial stressors modify associations between understudied chemicals and birth outcomes. • We studied the effect of psychosocial stressors and chemicals on birth outcomes. • We analyzed 1,556 mother-child pairs in the ECHO Cohort. • Stressors included adverse childhood experiences, depression, anxiety, and stress. • We observed some evidence of joint effects, particularly for phthalate exposures. • Future studies may consider co-exposure to multiple psychosocial stressors.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Psychosocial stressors as modifiers of the associations between well-studied and understudied chemicals and birth outcomes in the ECHO Cohort
- Date Crossref
- 01/01/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Emory University Department of Psychology pays non établi dans la noticeUniversité ou école supérieure
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University of North Carolina at Chapel Hill pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins University pays non établi dans la noticeUniversité ou école supérieure
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University of California Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
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New York University Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
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Kaiser Permanente pays non établi dans la noticeOrganisation à but non lucratif
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The State University of New Jersey Rutgers pays non établi dans la noticeUniversité ou école supérieure
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Environmental and Occupational Health Sciences Institute pays non établi dans la noticeUniversité ou école supérieure
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Seattle Children's Hospital pays non établi dans la noticeÉtablissement de santé
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Seattle Children's Research Institute pays non établi dans la noticeÉtablissement de santé
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University of Southern California pays non établi dans la noticeUniversité ou école supérieure
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Department of Psychology — Emory University, University of North Carolina at Chapel Hill et Johns Hopkins University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.