From Pediatrics to Adults: Evaluating Peripheral Globule Characteristics in Melanocytic Nevi and Their Clinical Implications

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Aim: Melanocytic nevi in children and adults can differ in growth rate, melanoma risk, and dermoscopic pattern.Peripheral globules (PGs) are common in both groups while being usually benign in pediatric patients and may increase melanoma risk in adults.We aimed to compare baseline and 12-month follow-up, characteristics of melanocytic lesions with PGs (MLPGs) in adult and paediatric age groups. Materials and Methods:A total of 170 MLPGs were evaluated morphologically; histopathological findings were reviewed when lesions were excised.Of these, 148 MLPGs had 12-month follow-up images and were analysed for changes in size, global pattern, and PGs.Results: At baseline, MLPGs in adults most commonly showed a homogeneous pattern, whereas MLPGs in children predominantly displayed a globular pattern.The distribution of PGs did not differ between age groups (P > 0.05).Adult nevi PG were more atypical (P = 0.001), whereas pediatric nevi PG were more regular (P = 0.001).After 12 months, no significant changes were observed in adults, while dynamic changes occurred in the paediatric group.Complete regression of PGs was more frequent in pediatric lesions (P = 0.046).Conclusion: MLPGs show distinct age-related behaviour: in adults, lesions remain largely stable while exhibiting more atypical PGs, whereas in children lesions evolve dynamically and PGs regress more frequently.

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