Plant-Derived Bioactives in Dual Disease Models: Experimental and Docking Insights on Antibacterial and Anticancer Targets

Le résumé fourni par la source

Natural plant-derived bioactives have attracted significant attention in recent years for their potential to address two global health challenges -infectious diseases and cancer -through complementary biochemical mechanisms.Many phytochemicals, including flavonoids, terpenoids, alkaloids, and limonoids, exhibit dual activity by disrupting microbial cell integrity and modulating cancer-associated signaling pathways such as EGFR, PI3K/Akt, and MAPK.This review integrates experimental and computational findings to explore how selected medicinal plants -including Azadirachta indica, Zingiber officinale, Simarouba glauca and others -demonstrate antibacterial efficacy while also exhibiting anticancer potential through receptor-level interactions.Experimental data reveal potent inhibition of bacterial growth via membrane disruption and enzyme inactivation, whereas molecular docking and dynamics analyses highlight strong binding affinities of phytocompounds with oncogenic protein targets, supporting their multitarget therapeutic nature.Collectively, these insights emphasize the emerging paradigm of plant bioactives as dual-function agents capable of bridging antimicrobial therapy and cancer chemoprevention.The review underscores the need for translational studies combining in vitro, in vivo, and in silico models to harness their pharmacological potential for integrated disease management.

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