Myosteatosis as an independent predictor for all-cause and cardiac mortality in initial-dialysis patients: a multicenter, retrospective cohort study
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Le résumé fourni par la source
Background: Myosteatosis is associated with adverse prognosis in diseases. We aimed to establish thresholds for myosteatosis, assess its association with all-cause and cardiac mortality in initial dialysis patients, and construct a myosteatosis-based survival nomogram. assessed the predictive value of myosteatosis with all-cause and cardiac mortality in initial-dialysis patients, and constructed a myosteatosis-based survival nomogram. Methods: ) and Skeletal Muscle Density (SMD, Hounsfield Units [HU]) were measured at the third lumbar vertebra (L3) level by computed tomography (CT). Sex-specific SMI and SMD thresholds predicted all-cause mortality through the receiver operating characteristic (ROC) curves. The Cox models assessed myosteatosis-associated mortality risks. Survival prediction models were built using univariate and multivariate Cox proportional hazards regression in the training cohort, followed by internal and external validation. Results: Patients were predominantly aged 18-65 years (n = 298, 77.81%), with males comprising 60.84% (n = 233). All-cause mortality was 22.72% (n = 87), of which 52.87% (n = 46) were attributed to cardiac causes. Sex-specific SMD cutoffs for predicting all-cause mortality were 32.46 HU (AUC = 0.707) in males and 34.58 HU (AUC = 0.690) in females (both P < 0.05). Myosteatosis was associated with higher all-cause (36.7%) and cardiac mortality (19.8%) (both P < 0.001), and independently predicted both outcomes (all-cause mortality: HR = 3.203, 95% CI:1.937-5.296; cardiac mortality: HR = 3.418, 95% CI:1.718-6.802). The myosteatosis-based nomogram achieved a C-index of 0.761, validated in real-world data. Conclusion: Sex-specific myosteatosis thresholds (males: SMD ≤32.46 HU; females: ≤34.58 HU) derived from L3-CT independently predicted all-cause and cardiac mortality in initial-dialysis patients. The myosteatosis-based survival nomogram demonstrated moderate-to-good predictive accuracy and potential clinical utility.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Myosteatosis as an independent predictor for all-cause and cardiac mortality in initial-dialysis patients: a multicenter, retrospective cohort study
- Date Crossref
- 26/11/2025
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Soochow University Department of Nephrology pays non établi dans la noticeUniversité ou école supérieure
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Zhongda Hospital Southeast University pays non établi dans la noticeÉtablissement de santé
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Nantong University pays non établi dans la noticeUniversité ou école supérieure
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Taizhou People's Hospital pays non établi dans la noticeÉtablissement de santé
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Northern Jiangsu People's Hospital pays non établi dans la noticeÉtablissement de santé
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Yangzhou University pays non établi dans la noticeUniversité ou école supérieure
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Southern University of Science and Technology Department of Nephrology pays non établi dans la noticeUniversité ou école supérieure
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Covenant Health pays non établi dans la noticeÉtablissement de santé
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Nanjing Medical University Department of intensive care unit pays non établi dans la noticeUniversité ou école supérieure
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School of Medicine Institute of Nephrology pays non établi dans la noticeUniversité ou école supérieure
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Institute of Nephrology pays non établi dans la noticeStructure de recherche
Department of Nephrology — Soochow University, Zhongda Hospital Southeast University et Nantong University, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.