High-grade serous ovarian cancer induced in different sites of origin in mice exemplifies diverse features of the human disease

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promoters or virally induced directly in the oviductal epithelium. We profiled the tumors by histology and gene expression and compared them to a previously described ovarian cancer model derived from ovarian surface epithelium. Expression profiles from the oviductal and ovarian epithelium tumors fall within the four subtypes of human high-grade serous carcinoma (HGSC) and represent different patient subpopulations. Allograft tumor models derived from the GEMs are amenable to preclinical intervention studies and respond to standard of care therapies. These well-defined, tractable models present a valuable resource for assessing novel drugs and immunotherapies for patients with HGSC.

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