Brain Volumetric Changes Post-COVID-19: A Systematic Review
Rattachement africain : Égypte, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: The potential long-term effects of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) infection on the brain structure have not yet been fully elucidated. Even though existing studies have reported structural changes in the post-COVID-19 period, the results remain highly inconsistent and controversial. As such, identifying an imaging biomarker for post-COVID brains is still under investigation. This review aims to comprehensively summarize the structural MRI (sMRI) studies that focus on volumetric brain changes at least two weeks following COVID-19 infection. Methods: A systematic literature search was conducted on PubMed, SCOPUS, Web of Science, EMBASE, and Google Scholar up to 9 September 2025. Studies that utilized sMRI to assess volumetric brain changes post-COVID at greater than two weeks following infection were included. Exclusion criteria encompassed research involving pediatric or adolescent populations and imaging modalities other than sMRI. Preprints, reviews, case reports, case series and post-mortem studies were also excluded. Results: Forty-one studies satisfied the inclusion criteria and consisted of 2895 patients and 1729 healthy controls. Despite the wide variability in image acquisition protocols, data processing methods, and comorbidities between studies, multiple studies reported statistically significant volumetric reductions in the hippocampus, amygdala, thalamus, basal ganglia, nucleus accumbens and the cerebellum months to years after infection, especially in older hospitalized patients with severe COVID-19. Conclusions: The emerging literature reports long-term volume changes across various brain regions in individuals previously infected with COVID-19; however, the evidence is inconsistent. Specific imaging biomarkers following exposure to SARS-CoV-2 infection and the underlying mechanisms of these changes are yet to be identified. Future studies with harmonized imaging protocols, longitudinal designs, and integrated biomarker and clinical data are needed to define robust biomarkers and elucidate the pathophysiology of these findings.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Brain Volumetric Changes Post-COVID-19: A Systematic Review
- Date Crossref
- 22/11/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Tanta University Tanta University, Égypte (code pays fourni par la source)Université ou école supérieure
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Mansoura University Mansoura University, Égypte (code pays fourni par la source)Université ou école supérieure
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Mayo Clinic in Arizona Department of Psychiatry and Psychology pays non établi dans la noticeÉtablissement de santé
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Mayo Clinic Hospital pays non établi dans la noticeÉtablissement de santé
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National Institutes of Health pays non établi dans la noticeOrganisme public
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National Institute on Drug Abuse Neuroimaging Research Branch pays non établi dans la noticeStructure de recherche
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Barrow Neurological Institute Department of Neurology pays non établi dans la noticeÉtablissement de santé
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Arizona State University Preclinical Imaging Core pays non établi dans la noticeUniversité ou école supérieure
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WinnMed pays non établi dans la noticeOrganisation à but non lucratif
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Mayo Clinic in Florida pays non établi dans la noticeÉtablissement de santé
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Mayo Clinic Department of Psychiatry and Psychology pays non établi dans la noticeÉtablissement de santé
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Faculty of Medicine Department of Medical Physiology Tanta University, Égypte (pays nommé en fin d’affiliation)Université ou école supérieure
Tanta University (Tanta University, Égypte), Mansoura University (Mansoura University, Égypte) et Department of Psychiatry and Psychology — Mayo Clinic in Arizona, avec 9 autres affiliations. Pays d’affiliation : Égypte.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.