Mapping the Severe Asthma Questionnaire to EQ-5D-5L health utility scores in the SHARP CRC registry

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Rationale The Severe Asthma Questionnaire (SAQ) provides insight into patients' perceptions of severe asthma. However, policy makers often prefer preference-based measures (PBMs) as the EuroQol-5D-5L (EQ5D5L) to estimate health-related quality of life for use in health-economic evaluations. Aim To develop mapping algorithms based on the SAQ score and SAQ domains for the EQ5D5L health utility scores. Methods We included all 316 patients with EQ5D5L data (7 countries, 55% female, mean age 54 (SD 13)) years, 77% on biologics, mean ACQ6 score 1.7 (SD 1.3), mean SAQ score 5.1 (SD 1.6) from the Severe Heterogeneous Asthma Research collaboration Patient-centred (SHARP) registry. Direct mapping of the EQ5D5L index (OLS, betamix regression) or indirect mapping (oprobit) of the 5 dimensions: mobility; self-care; usual activities; pain/discomfort; anxiety/depression) was based on the SAQ score and SAQ domains (my life: impact on life activities; my mind: emotional impact; my body: impact on extra-pulmonary symptoms and side effects). Model performance was based on the mean (SD), (lowest) root mean square error (RMSE) and the explained variance (R2). Results erj;66/suppl_69/PA3643/F1 F1 F1 CONCLUSION In the absence of the preference-based EQ5D5L, the indirect mapping of SAQ domains-based algorithm provides a good alternative for predicting the health utility in patients with severe asthma for use in health-economic evaluations. Funding: SHARP CRC, RAPSODI

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