Obstructive sleep apnea, obesity and SCORE2 cardiovascular risk in a middle-aged population - the SCAPIS Sleep Cohort

Le résumé fourni par la source

Study objectives We investigated the prevalence of obstructive sleep apnea (OSA) and obesity and their associations with elevated cardiovascular (CV) risk in the general population. Methods: A total of 9014 participants (age 50-64 years, 46.4% males) from Gothenburg, Uppsala and Umeå in the Swedish CArdioPulmonary bioImage Study (SCAPIS) underwent a home sleep apnea test along with anthropometrics, blood sampling and CT angiography. Mild/moderate /severe OSA was categorized by apnea-hypopnea index 5-14.9, 15-29.9 and ≥30 events/h, respectively. Obesity was defined as BMI >40 kg/m2 or ≥30 kg/m2 with waist-to-hip ratio >0.90 for men and >0.85 for women (Rubino, F. et al. Lancet Diabetes Endocrinol, 2025). Systematic COronary Risk Evaluation 2 (SCORE2) was used to assess 10-year risk of first-onset CV disease. SCORE2 risk ≥10% was classified as a very-high CV risk. Results: The prevalence of mild, moderate, severe OSA and obesity was 35.1%, 9.5%, 3.1%, and 18.4%, respectively. Compared to the non-OSA group, a dose-response association between OSA severity and elevated SCORE2 risk was revealed after controlling for anthropometrics, comorbidities, coronary artery calcification, and hsCRP (odds ratio[95%CI]: mild 1.30 [1.02-1.65], moderate 2.43 [1.79-3.29], severe 2.58 [1.66-3.99], p=0.031, <0.001 and <0.001, respectively). In the same logistic regression model, obesity was associated with increased odds of “very-high CV risk” (1.37 [1.08-1.74], p=0.009). Conclusions: We found high prevalences of both OSA and obesity (new definition) in the middle-aged Swedish population. OSA and obesity should be considered as modifiable risk factors in preventive cardiology. *co-last authors

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.