Assessing the accuracy of molecular flow sensing for the measurement of oxygen consumption

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Background: Existing techniques for monitoring oxygen consumption (V̇O2) in critical care are often inaccurate, invasive, or both. We introduce the molecular flow sensor (MFS), a novel device that measures V̇O2 directly in the main airway without sampling delay. Aim: To assess the accuracy of MFS V̇O2 measurement compared with the Douglas Bag (DB). Methods: Participants were studied at rest for 10 minutes. Simultaneous V̇O2 measurements were made with the MFS and DB, connected in series via a valve system. The MFS combines in-airway laser-absorption spectroscopy and a precision bidirectional flow sensor to record oxygen concentration and flow every 10 milliseconds. This eliminates time delays and the need to use the Haldane transformation. For DB, mixed expired gas was analysed for volume (gas meter) and composition (gas analyser), and V̇O2 determined using the Haldane transformation. Results: 16 healthy volunteers were enrolled. MFS-measured V̇O2 demonstrated excellent agreement with DB (Fig. 1A; r=0.921; p<0.0001). Bland-Altman analysis (Fig. 1B) revealed an average percentage V̇O2 difference between methods of -3.07% (MFS V̇O2 > DB V̇O2). Limits of agreement ranged from +12.23% to -18.38%. Conclusion: The MFS accurately measures V̇O2, offering the potential for a non-invasive, real-time alternative for V̇O2 monitoring in critical care. erj;66/suppl_69/PA4191/F1 F1 F1

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