The effect of comorbidity burden on exercise tolerance in chronic obstructive pulmonary disease

Résumé fourni par la source

Introduction: Reduced exercise tolerance is a hallmark symptom of COPD and a strong predictor of morbidity and mortality. Comorbidities are associated with poorer outcomes in COPD; however, it remains unclear if the number of comorbidities impacts exercise tolerance, and whether this varies across different exercise tests. Aim: Determine whether number of comorbidities impacts exercise tolerance and if it differs between commonly used field and laboratory-based exercise tests. Methods: Participants attended two study visits on consecutive days for the purpose of a randomised control trial. At visit 1, participants performed a ramp-incremental cycle exercise test (RIT), incremental shuttle walk test (ISWT) and six-minute walk test (6MWT). At visit 2, participants completed a constant work rate cycle test (CWRCT), 4 m gait speed test (4MGS), and endurance shuttle walk test (ESWT). Results: 103 participants completed all tests (67 ± 8 years; 73% male). Comorbidities were 0 (n=15), 1 (n=26), 2 (n=31) and ≥3 (n=31). 4MGS was greater in those with ≥3 comorbidities compared to those with no comorbidities (p=0.01; Table 1). There were no other differences in test outcome measures between participants with 0, 1, 2 or ≥3 comorbidities (p>0.05; Table 1). Conclusion: In this COPD cohort, when measured using field or laboratory-based exercise tests, exercise tolerance may not be adversely affected by number of comorbidities. erj;66/suppl_69/PA3921/F1 F1 F1

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