Trust your gut: Are gut microbial species associated with asthma?

Le résumé fourni par la source

Introduction: The gut microbiome is implicated in respiratory disease including asthma, however few large-scale studies assessing its composition in adults with asthma exist. Objectives: To determine if there is a specific gut microbial composition in adults with asthma. Methods: This cross-sectional analysis included 8831 adults, aged 50–64years, from the population-based Swedish CArdioPulmonary bioImage Study. Associations between gut microbiota (exposure) and current asthma (outcome, n=526) were assessed in conditional logistic regression models, adjusted for age, sex, plate, country of birth (basic) smoking status, education, physical activity and fibre intake and BMI (extended). Benjamini-Hochberg corrections (FDR cut-off of 0.10) was used. Results: We found 215 and 134 species in the basic and extended model, respectively. In extended models, each doubling of Streptococcus mutans relative frequency was associated with 6.7% higher odds of asthma (q=1.0*10-6) and each doubling of Lentihominibacter sp905193765 relative frequency was associated with 4.2% lower odds of asthma (q=0.001). Higher microbial diversity was significantly associated with lower odds of asthma; Shannon’s index OR: 0.747 (0.602, 0.925). In sub-analyses, after excluding other respiratory disease (n=8633), chronic diseases (n=4414), use of antibiotics (n=7713), proton-pump inhibitors (n=7741), systemic steroids (n=8425) (all medication use in past 6 months), we found 101, 37, 67, 31 and 66 species associated with asthma, respectively. Conclusion: We found a specific gut microbial composition and lower microbial diversity in adults with asthma. Further studies are needed to determine the benefits of alterations in gut microbiota in asthma.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.