Incidence of GP-attended respiratory syncytial virus (RSV), human metapneumovirus (HMPV) and human parainfluenza virus (HPIV) amongst high-risk patients in Europe

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Introduction: RSV, HMPV and HPIV respiratory tract infections (RTI) are associated with morbidity and mortality, particularly in elderly and those with risk factors. There is a paucity of data on incidences and clinical burden of these viruses in patients attending primary care with RTI, which is relevant in vaccine development. Methods: In an Ecraid Perpetual Observational Study we estimate incidences of RSV, HMPV and HPIV in older and high-risk patients attending their GP with an RTI. A recruitment schedule, informed by expected incidence patterns (Jan: 46, Jul: 22), is implemented over 12 consecutive months per country. Patients ≥60 and 50-59 eligible for influenza vaccination (targets), consulting with RTI symptoms ≤10 days are included. A nose/throat swab is taken for PCR analysis and patients are followed for 28 days (symptoms, recovery, EQ-5D, re-consultations, complications). Numbers of target patients presenting monthly with RTI symptoms are gathered per practice for incidence estimations, see example for Dec’24 UK: erj;66/suppl_69/OA2203/TB1 T1 TB1 Registered targets RTI consultations by targets % RSV+ Estimated monthly incidence GP-attended RSV 23,977 345 8.6% 1.24/1000 targets Results: The study is enrolling in UK, France and Spain and will open in Italy and Germany Q1’25. Preliminary results show expected patterns of viral pathogens: erj;66/suppl_69/OA2203/F1 F1 F1 Discussion: Updated results will be discussed.

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