Appetite and longitudinal effects on weight and muscle function in COPD

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Introduction: The Simplified Nutritional Appetite Questionnaire (SNAQ) is a brief appetite screening tool (scores from 4-20 with ≤ 14 indicating poor appetite). We hypothesised that poor appetite is associated with accelerated loss of weight, muscle mass and muscle strength. Methods: Participants: Individuals with stable COPD (SNAQ≤ 14; n=35 and 1:1 propensity score matched comparator group with SNAQ ≥15). Study design: Prospective cohort over one year. Measures: Body mass index (BMI), fat free mass (FFM) determined using bioelectrical impedance and a disease specific equation, ultrasound derived rectus femoris cross sectional area (RFCSA), quadriceps maximal voluntary contraction (QMVC). Analysis: Between group comparison of change in BMI, FFM, RFCSA and QMVC over one year. Results: Baseline characteristics: 55% male; mean (SD) age 70(9.3) years; BMI 28.8(6.1); FEV1 54.6(18.6) % predicted. Groups were well matched for baseline variables. No significant between group changes in BMI, FFM, RFCSA, QMVC were observed (table 1). erj;66/suppl_69/PA5187/TB1 T1 TB1 Variable SNAQ ≤14 SNAQ ≥15 Between group difference ΔBMI (kg/m2) -0.26(-0.8 to 0.3) -0.37 (-0.9 to 0.2) 0.1 (-0.7 to 0.9) ΔFFM (kg) 0.50 (-0.26 to 1.2) 0.31 (-1.0 to 1.6) 0.17 (-1.3 to 1.6) ΔRFCSA (mm2) -3.0 (-48.3 to 42.1) -45.3 (-76.2 to -14.4) 42.2 (-11.6 to 96.0) ΔQMVC (kg) -1.6 (-3.8 to 0.7) -1.9 (-5.0 to 1.1) 0.4 (-3.4 to 4.2) Data presented as 95% (CI) Conclusion: In people with COPD, poor appetite was not associated with accelerated loss in weight, muscle mass or muscle strength over 12 months.

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