Annual variation in intensive care mortality of women with acute respiratory failure: A 11-year cohort study

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Aim: Life expectancy favors for women. Women have a lower intensive care unit ICU mortality rate. We examined the changing annual mortality of women in respiratory ICU over 11 years. Method. The retrospective cohort study was conducted in the respiratory ICU of a teaching hospital between 2013 and 2024. Every ICU hospitalized patient was included in the study. Sex, mortality, pneumonia diagnosis, ventilation types were recorded. Annual percent change (APC) was evaluated by joinpoint analysis. Results: The 17670 (6310 female, 29.6%) patients were studied. The annual mortality change in overall ICU mortality in women was APC -2.0 (CI:-14.7; 12.4, p=0.28) in 2013-19 and APC 5.8 (-7.88; 22.57, p=0.09) in 2019-24. APC mortality among women have significant fragmentations: 2013-16: 9.8 (0.9-33.1, p=0.041), 2016-19: -12.2(-18.8;-2.47, p=0.034), and 2019-24: 11.6 (5.3;31.5, p=0.011) (Fig 1). In 2013-15, men's APC of mortality was 18.9 (6.6;12.1, p=0.002), in 2015-18, -13.6 (-17.7;-6.8), and in 2018-24, 7.6 (4.8;13.0, p=0.001)(Fig 2). Conclusion: The variation in ICU mortality over the years reflects epidemic patterns, and the mortality rates for women climbed more than those for men during the last pandemic. The SarsCoV2 pandemic revealed a more deadly prognosis for women. erj;66/suppl_69/PA1010/F1 F1 F1

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