Linking mucus plugs and chronic bronchitis to bronchodilator responsiveness in young adult smokers: BEACON cohort

Résumé fourni par la source

BACKGROUND: In COPD and asthma, mucus plugging is common but poorly corresponds to symptoms. To investigate if plugging and chronic bronchitis reflect different mucus dysfunction phenotypes, we assessed how their presence/absence related to airway hyper-responsiveness in young adult smokers. METHODS: The British Early COPD Network (BEACON) enrolled 30–45-year-old smokers with ≥10 pack year smoking history and FEV1%predicted≥80% without diagnosed/treated asthma. We compared FEV1 bronchodilator reversibility and blood eosinophil count according to the presence/absence of both chronic bronchitis (clinical, CAT, MRC and SGRQ definitions) and mucus plugs (full inspiratory CT thorax scan). RESULTS: Among 404 BEACON subjects (60% male; 82% Caucasian; median age 39 (IQR:35-42) years; median pack years 16 (IQR:12-21); FEV1% 100% (IQR:93-109)), 192(48%) reported chronic bronchitis (any definition), 38(9%) had mucus plugs. Those with plugs had greater FEV1 reversibility: 185(IQR:85-253) vs 130(IQR:50-220)mL(P=0.04) and more frequently had bronchodilator responsiveness than those without (P=0.03). We found no difference by chronic bronchitis presence and no differences in eosinophil counts (Fig.1). CONCLUSION: FEV1 reversibility was over-represented among those with mucus plugs, but not among those with chronic bronchitis, potentially indicating different pathological processes present among young adult smokers. erj;66/suppl_69/OA6435/F1 F1 F1

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.