Multi-domain cognitive function in COPD and matched controls: Baseline data from the COPD-HIIT randomised controlled trial

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Background Cognitive impairment is increasingly recognized as an extrapulmonary manifestation of COPD, yet little is known across cognitive domains and associations with exercise capacities and inflammation remain underexplored. Aims and objectives: To compare cognitive function in COPD and age-, sex- and physical activity matched healthy controls (HCs) and examine associations with exercise performance and systemic inflammation. Methods: Multi-domain cognitive function was assessed at baseline in 44 individuals with COPD and 39 matched HCs. Correlations of exercise performance including CPET Wpeak and anaerobic capacity (Borg cycle strength test [BCST Wpeak]) and inflammation were analysed. Results: COPD participants exhibited lower cognitive function across most domains compared to HCs (Table 1). In COPD, BCST Wpeak correlated with trail making tests ([TMT] TMT-A: r=-.43; TMT-B: r=-.32; p<0.05)) visual processing (VP1: r=.43; p<0.05) and memory (PAL: r=.35; p<0.05), while CPET Wpeak showed no associations. Higher fibrinogen levels correlated with poorer TMT-B and PAL1 performance (r=.38 & r=-.40; p<0.05). Conclusion: Cognitive impairment spans across multiple domains in COPD, even in those with relatively preserved fitness and lung function. Cognitive deficits were associated to anaerobic, but not aerobic exercise capacity and were associated with systemic inflammation in some, but not all domains. erj;66/suppl_69/OA6462/F1 F1 F1

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