Demographic and Disease Characteristics from A Phase I/II Trial of Oral SRA737 (a Chk1 Inhibitor) Given in Combination with Low-Dose Gemcitabine in Patients with Advanced Cancer

Le résumé fourni par la source

Patients are displayed in cohorts defined by tumor type, including indication-specific expansion cohorts (anogenital, cervical, HGSOC, SCLC and STS), a grouping of patients with rectal cancer who were enrolled under dose escalation, and four patients with urothelial cancer enrolled under previous protocol versions. A total of 18 patients were “double counted” in that they appear under both “All dose escalation” and in their specific tumor-type cohorts. These 18 patients consisted of 15 dose-escalation patients with rectal cancer, one dose-escalation patient with anogenital cancer, one concurrently enrolled dose-escalation/expansion patient with cervical cancer, and one concurrently enrolled dose-escalation/expansion patient with STS.

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