Figure 3 from ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance
Le résumé fourni par la source
ATM inhibition reverses the myofibroblast CAF phenotype and inhibits function. A–C, Western blotting of HNSCC (A) and NSCLC (B) CAF treated with KU55933 for 7 days and their quantification (C). D, qRT-PCR of CAF (NSCLC, n = 1; HNSCC, n = 2) stably expressing either shCTR or shATM (ntr = 3). E, Collagen gel contraction assay and measurement of gel area of shCTR or shATM HNSCC and NSCLC CAF (left, representative gel images; ntr = 2). F and G, Transwell invasion assays of H441 (F) or 5PT (G) cells toward CAF-conditioned media generated from NSCLC (nbr = 3; ntr = 3–5; F) and HNSCC (nbr = 8; ntr = 2–4; G) treated as in A (means are shown and two-way ANOVA is used and refers to the control). Heteroscedastic Student t test is shown throughout the figure and refers to the control unless otherwise stated. *, P ≤ 0.05; **, P ≤ 0.01.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Figure 3 from ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance
- Date Crossref
- 24/11/2025
- Éditeur
- American Association for Cancer Research (AACR)
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.