Figure 7 from Extracellular Vesicle Secretion by Leukemia Cells In Vivo Promotes CLL Progression by Hampering Antitumor T-cell Responses

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Expression of sEV-related genes correlates with disease progression and poor survival in CLL patients. Gene-expression analysis was performed by RT-qPCR for 7 genes involved in sEV biogenesis and secretion in a cohort of 144 CLL patients. The correlation between gene expression and survival was evaluated by Cox univariate regression analysis. Gene expression in clinical groups was evaluated by differential expression analysis for single genes or by logistic regression (LR) analysis for multiple genes. A, Calculated hazard ratios >1 (red dots, P < 0.05) indicate an increased risk for patients with high single-gene expression in terms of OS. B, Correlation between high or low gene expression and OS. Low and high groups are of identical size (n = 72) Median OS is indicated in months (mo). C, Correlation between high or low combined 7-gene expression and OS. D, Calculated hazard ratios >1 (red dots, P < 0.05) indicate an increased risk for patients with high multiple gene expression in terms of OS. E, Calculated hazard ratios >1 (red dots, P < 0.05) indicate an increased risk for patients with high single-gene expression in terms of TFS. F, Correlation between high or low gene expression and TFS. G and H, Standardized expression of single genes (G) or LR scores for multiple genes (H) in groups of patients according to prognostic markers (CytoG, cytogenetics, group size indicated in each panel). *, P < 0.05; **, P < 0.01. Data are mean with 95% confidence intervals.

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